Doctoral Program in Molecular and Cell Biology
2024
Bento CM, Calster KV, Piller T, Oliveira GS, Vooght LD, Cappoen D, Cos P, Gomes MS, Silva T (2024) Characterization of novel double-reporter strains of Mycobacterium abscessus for drug discovery: a study in mScarlet. Microbiology Spectrum 0:e00362-24. DOI: 10.1128/spectrum.00362-24
Cardoso MS*, Gonçalves R*, Oliveira L, Silvério D, Téllez É, Paul T, Sarrias MR, Carmo AM, Saraiva M (2024) CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression, Immunology. https://doi.org/10.1111/imm.13825 *co-authors
Carvalho C, Barbosa DJ, Celestino R, Zanin E, Carvalho AX, Gassmann R 2024. Dynein directs prophase centrosome migration to control the stem cell division axis in the developing Caenorhabditis elegans epidermis, Genetics 226(3): iyae005. https://doi.org/10.1093/genetics/iyae005
Carvalho, E., Dias, A., Coelho, T. et al. Hereditary transthyretin amyloidosis: a myriad of factors that influence phenotypic variability. J Neurol (2024). https://doi.org/10.1007/s00415-024-12509-8
Gaifem J*, Rodrigues CS*, Petralia F, Alves I, Leite-Gomes E, et al. A unique serum IgG glycosylation signature predicts development of Crohn’s disease and is associated with pathogenic antibodies to mannose glycan. Nature Immunology. 2024. DOI: 10.1038/s41590-024-01916-8
Martins TS, Correia M, Pinheiro D, Lemos C, Mendes MV, Pereira C, Costa V (2024) Sit4 genetically interacts with Vps27 to regulate mitochondrial function and lifespan in Saccharomyces cerevisiae. Cells 13(8), 655. doi: 10.3390/cells13080655.
Meireles D, Pombinho R, Cabanes D. Signals behind Listeria monocytogenes virulence mechanisms. Gut Microbes. 2024 Jan-Dec;16(1):2369564. doi: 10.1080/19490976.2024.2369564.
Oliveira da Silva MI, Santejo M, Babcock IW, Magalhães A, Minamide LS, Won SJ, Castillo E, Gerhardt E, Fahlbusch C, Swanson RA, Outeiro TF, Taipa R, Ruff M, Bamburg JR, Liz MA. α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway. Cell Death Dis. 2024 Apr 13;15(4):264. doi: 10.1038/s41419-024-06630-9. PMID: 38615035; PMCID: PMC11016063.
Rafaela Abrantes, Cátia C. Ramos, Ezequiel R. Coscueta, João Costa, Joana Gomes, Catarina Gomes, Celso A. Reis, Maria Manuela Pintado. "Effects of microencapsulated phenethyl isothiocyanate on gastrointestinal cancer cells and pathogenic bacteria". Food Bioscience, Volume 61, October 2024, 104950. https://doi.org/10.1016/j.fbio.2024.104950.
Ramos CC, Pires J, Gonzalez E, Garcia-Vallicrosa C, Reis CA, Falcon-Perez JM, Freitas D. 2024. "Extracellular vesicles in tumor-adipose tissue crosstalk: key drivers and therapeutic targets in cancer cachexia" Extracellular Vesicles and Circulating Nucleic Acids. 5, no.3: 471-96. http://dx.doi.org/10.20517/evcna.2024.36
Ribeiro C, Ferreirinha P, Landry JJM, Macedo F, Sousa LG, Pinto R, Benes V, Alves NL. Foxo3 regulates cortical and medullary thymic epithelial cell homeostasis with implications in T cell development. Cell Death Dis. 2024 May 21;15(5):352. https://doi.org/10.1038/s41419-024-06728-0.
Silva, A. I., Socodato, R., Pinto, C., Terceiro, A. F., Canedo, T., Relvas, J. B., Saraiva, M., & Summavielle, T. (2024). IL-10 and Cdc42 modulate astrocyte-mediated microglia activation in methamphetamine-induced neuroinflammation. Glia, 72(8), 1501–1517. https://doi.org/10.1002/glia.24542
Silva, E.D.; Pereira-Sousa, D.; Ribeiro-Costa, F.; Cerqueira, R.; Enguita, F.J.; Gomes, R.N.; Dias-Ferreira, J.; Pereira, C.; Castanheira, A.; Pinto-do-Ó, P.; et al. Pericardial Fluid Accumulates microRNAs That Regulate Heart Fibrosis after Myocardial Infarction. Int. J. Mol. Sci. 2024, 25, 8329. https://doi.org/10.3390/ijms25158329
Varela, R.*, Gonzalez-Ortiz, F*., Dias, A.*, Knuth, N. L., Fonte, J., Pinto, B., ... & Maia, L. F. (2024). Plasma Brain-Derived Tau in Prognosis of Large Vessel Occlusion Ischemic Stroke. Stroke. doi: 10.1161/STROKEAHA.123.046117
2023
Brito, C.; Pereira, J.M.; Mesquita, F.S.; Cabanes, D.; Sousa, S. Src-Dependent NM2A Tyrosine Phosphorylation Regulates Actomyosin Remodeling. Cells 2023, 12, 1871. https://doi.org/10.3390/cells12141871.
Cavaco, S., Sousa, G., Gonçalves, A., Dias, A., Andrade, C., Pereira, D., ... & Correia, M. (2023). Predictors of cognitive dysfunction one-year post COVID-19. Neuropsychology, 37(5), 557. doi:10.1037/neu0000876
Faria L, Canato S, Jesus TT, Gonçalves M, Guerreiro PS, Lopes CS, Meireles I, Morais-de-Sá E, Paredes J, Janody F (2023). Activation of an actin signalling pathway in premalignant mammary epithelial cells by P-cadherin is essential for transformation. Disease Models & Mechanisms 16(2). DOI: https://doi.org/10.1242/dmm.049652
Felício, D.; du Mérac, T.R.; Amorim, A.; Martins, S. Functional implications of paralog genes in polyglutamine spinocerebellar ataxias. Hum Genet 2023, 142:1651-1676. https://doi.org/10.1007/s00439-023-02607-4
Figueira, A. J., Moreira, G. G., Saavedra, J., Cardoso, I., & Gomes, C. M. (2022). Tetramerization of the S100B Chaperone Spawns a Ca2+ Independent Regulatory Surface that Enhances Anti-aggregation Activity and Client Specificity. Journal of molecular biology, 434(19), 167791. https://doi.org/10.1016/j.jmb.2022.167791
Figueira, A. J., Saavedra, J., Cardoso, I., & Gomes, C. M. (2023). S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation. Frontiers in neuroscience, 17, 1162741. https://doi.org/10.3389/fnins.2023.1162741
Figueiredo AS, Loureiro JR, Macedo-Ribeiro S, Silveira I. Advances in Nucleotide Repeat Expansion Diseases: Transcription Gets in Phase. Cells. 2023; 12(6):826. https://doi.org/10.3390/cells12060826
Garcia-Pelaez, J., Barbosa-Matos*, R., Lobo, S.*, Dias, A.*, Garrido, L., Castedo, S., ... & Oliveira, C. (2023). Genotype-first approach to identify associations between CDH1 germline variants and cancer phenotypes: a multicentre study by the European Reference Network on Genetic Tumour Risk Syndromes. The Lancet Oncology, 24(1), 91-106. doi:10.1016/S1470-2045(22)00643-X
Gonçalves-Santos F, De-Castro MJG, De-Castro ARG, Dantas TJ. Building train carriages for ciliary transport: (IFT-)A complex task. Commun Biol (2023). DOI: https://doi.org/10.1038/s42003-023-04426-9
Gonçalves-Santos F*, De-Castro ARG*, Rodrigues DRM, De-Castro MJG, Gassmann R, Abreu CM, Dantas TJ. Hot-wiring dynein-2 uncovers roles for IFT-A in retrograde train assembly and motility. Cell Reports (2023). DOI: https://doi.org/10.1016/j.celrep.2023.113337
Gonzalez-Ortiz, F., Dias, A., Turton, M., Magalhães, R., Kac, P. R., Correia, M., ... & Karikari, T. K. (2023). Preanalytical stability of plasma/serum brain-derived tau. Alzheimer's & Dementia, 19(10), 4764-4770 doi: 10.1111/ane.13668
Leite AC, Barbedo M, Costa V, Pereira C (2023) The APC/C activator Cdh1p plays a role in mitochondrial metabolic remodelling in yeast. Int J Mol Sci 24, 4111. doi: 10.3390/ijms24044111.
Leite AC, Martins TS, Cesario RR, Teixeira V, Costa V, Pereira C (2023) Mitochondrial respiration promotes Cdc37-dependent stability of the Cdk1 homolog Cdc28. J Cell Science 136, jcs260279. doi:10.1242/jcs.260279.
Maceiras AR, Silvério D, Gonçalves, R, Cardoso MS, Saraiva M (2023) Infection with hypervirulent Mycobacterium tuberculosis triggers emergency myelopoiesis but not trained immunity, Frontiers in Immunology, 14, 1211404. https://doi.org/10.3389/fimmu.2023.1211404
Martins TS, Costa, RS, Vilaça R, Lemos C, Teixeira V, Pereira C, Costa V (2023) Iron limitation restores autophagy and increases lifespan in the yeast model of Niemann–Pick type C1. Int J Mol Sci 24, 6221. doi:10.3390/ijms24076221.
Moreira J, Costelha S, Saraiva, M, Saraiva MJ. The expression of chemokines is downregulated in a pre-clinical model of TTR V30M amyloidosis". Frontiers in Immunology.19;12:650269. doi: 10.3389/fimmu.2021.650269. eCollection 2021.
Moreira J, Martins S, Saraiva M, Saraiva MJ. Decreased expression of S100A8/A9 in V30M related ATTRv amyloidosis. Amyloid 22:1-8, 2023.
Moreira J, Martins H, Saraiva M, Saraiva MJ. TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with down-regulated expression of chemokines. Clin Sci (Lond). 137(5):355-366, 2023
Oliveira AC, Santos M, Pinho M, Lopes CS. String/Cdc25 phosphatase is a suppressor of Tau-associated neurodegeneration. Dis Model Mech. 2023 Jan 1;16(1):dmm049693. doi: 10.1242/dmm.049693. Epub 2023 Jan 23. PMID: 36601903; PMCID: PMC9903143.
Poças J, Marques C, Gomes C, Otake AH, Pinto F, Ferreira M, Silva T, Faria-Ramos I, Matos R, Ribeiro AR, Senra E, Cavadas B, Batista S, Maia J, Macedo JA, Lima L, Afonso LP, Ferreira JA, Santos LL, Polónia A, Osório H, Belting M, Reis CA, Costa-Silva B, Magalhães A. Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2214853120. doi: 10.1073/pnas.2214853120. Epub 2023 May 8. PMID: 37155874; PMCID: PMC10193992.
Raposo, Luís; Cerqueira, Rui J. ; Leite, Sara; Moreira-Costa, Liliana; Laundos, Tiago L.; Miranda, Joana O.; Mendes-Ferreira, Pedro; Coelho, João Almeida; Gomes, Rita N.; Pinto-do-Ó, Perpétua; Nascimento, Diana S.; Lourenço, André P.; Cardim, Nuno; Leite-Moreira, Adelino. Human-umbilical cord matrix mesenchymal cells improved left ventricular contractility independently of infarct size in swine myocardial infarction with reperfusion. Frontiers in Cardiovascular Medicine 2023, 10. https://doi.org/10.3389/fcvm.2023.1186574
Saavedra J, Nascimento M, Liz MA, Cardoso I. Key brain cell interactions and contributions to the pathogenesis of Alzheimer's disease. Front Cell Dev Biol. 2022 Nov 29;10:1036123. doi: 10.3389/fcell.2022.1036123. PMID: 36523504; PMCID: PMC9745159.
Teixeira C, Martins HS, Saraiva MJ. Cellular environment of TTR deposits in an animal model of ATTR-Cardiomyopathy. Front Mol Biosci. 10:1144049, 2023
Vicente MM, Leite-Gomes E, Pinho SS. Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications. Trends Immunology. 2023 DOI: 10.1016/j.it.2023.06.004
2022
Alves S, Pereira JM, Mayer RL, Gonçalves ADA, Impens F, Cabanes D, Sousa S (2022). Cells Responding to Closely Related Cholesterol-Dependent Cytolysins Release Extracellular Vesicles with a Common Proteomic Content Including Membrane Repair Proteins. Toxins, 15(1), 4. https://doi.org/10.3390/toxins15010004
Barros-Carvalho, A., and Morais-de-Sa, E. (2022). Balancing cell polarity PARts through dephosphorylation. J Cell Biol 221. DOI: 10.1083/jcb.202208008
Biller SJ, Muñoz-Marín MdC, LIMA S, Matinha-Cardoso J, Tamagnini P, Oliveira P (2022) Isolation and Characterization of Cyanobacterial Extracellular Vesicles. J. Vis. Exp. (180): e63481 DOI: 10.3791/63481
Bordeira-Carriço R*, Teixeira J*, Duque M*, Galhardo M, Ribeiro D, Dominguez-Acemel R, Firbas PN, Tena JJ, Eufrasio A, Marques J, Ferreira FJ, Freitas T, Carneiro F, Goméz-Skarmeta J-L, Bessa J (2022) Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers. Nat Commun 13:1945. DOI: 10.1038/s41467-022-29551-7; *Equal contribution as first author
Bravo, J., I. Ribeiro, A. F. Terceiro, E. B. Andrade, C. C. Portugal, I. M. Lopes, M. M. Azevedo, M. Sousa, C. D. F. Lopes, A. C. Lobo, T. Canedo, J. B. Relvas, and T. Summavielle (2022). "Neuron-Microglia Contact-Dependent Mechanisms Attenuate Methamphetamine-Induced Microglia Reactivity and Enhance Neuronal Plasticity." Cells 11 (3). doi: 10.3390/cells11030355.
Costa AC, Sousa MM (2022) The Role of Spastin in Axon Biology. Front Cell Dev Biol 10:934522. DOI: 10.3389/fcell.2022.934522
Dias, A., Silva, L., Moura, J., Gabriel, D., & Maia, L. F. (2022). Fluid biomarkers in stroke: From animal models to clinical care. Acta Neurologica Scandinavica, 146(4), 332-347. doi: 10.1002/alz.13156
Duque P, Vieira CP, Bastos B, Vieira J (2022) The evolution of vitamin C biosynthesis and transport in animals. BMC Ecol Evol 22(1):84. DOI: 10.1186/s12862-022-02040-7
Duque P, Vieira CP, Vieira J (2022). Advances in Novel Animal Vitamin C Biosynthesis Pathways and the Role of Prokaryote-Based Inferences to Understand Their Origin. Genes, 13(10), 1917. https://doi.org/10.3390/genes13101917
Ferreira JM, Jorge S, Félix L, Morello GM, Olsson IAS, Valentim AM (2022). Behavioural Aversion and Cortisol Level Assessment When Adult Zebrafish Are Exposed to Different Anaesthetics. Biology, 11(10), 1433.
Ferreirinha P, Pinheiro RGR, Landry JJM, Alves NL. Identification of fibroblast progenitors in the developing mouse thymus. Development. 2022 May 15;149(10):dev200513. doi: 10.1242/dev.200513. Epub 2022 May 26.
Figueiredo, J., Ferreira, R.M., Xu, H., Goncalves, M., Barros-Carvalho, A., Cravo, J., Maia, A.F., Carneiro, P., Figueiredo, C., Smith, M.L., et al. (2022). Integrin beta1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells. Gastric Cancer 25, 124-137. DOI: 10.1007/s10120-021-01239-9
Freitas IL, Teixeira A, Loureiro I, Lisboa J, Saraiva A, dos Santos NMS, do Vale A (2022) Susceptibility of Sea Bream (Sparus aurata) to AIP56, an AB-Type Toxin Secreted by Photobacterium damselae subsp. piscicida. Toxins 14:119. DOI: 10.3390/toxins14020119
Gião T, Teixeira T, Almeida MR, Cardoso I (2022) Choroid Plexus in Alzheimer's Disease-The Current State of Knowledge. Biomedicines 10(2):224. DOI: 10.3390/biomedicines10020224
Gomes AM, Orr B, Novais-Cruz M, De Sousa F, Monteiro JM, Lemos C, Ferrás C, Maiato H (2022). Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells, Current Biology, 32, 4240–4254
Henriques SN, Oliveira L, Santos RF, Carmo AM (2022). CD6-mediated inhibition of T cell activation via modulation of Ras. Cell Commun Signal, 20(1), 184. https://doi.org/10.1186/s12964-022-00998-x
Leite AC, Martins TS, Campos A, Costa V, Pereira C (2022). Phosphoregulation of the ATP synthase beta subunit stimulates mitochondrial activity for G2/M progression, Advances in Biological Regulation, 85:100905
Lima S, Matinha-Cardoso J, Giner-Lamia J, Couto N, Pacheco CC, Florencio F J, Wright PC, Tamagnini P, Oliveira P (2022) Extracellular vesicles as an alternative copper-secretion mechanism in bacteria. Journal of Hazardous Materials 431:128594. DOI: 10.1016/j.jhazmat.2022.128594
Liu Q, Reed M, Zhu H, Cheng Y, Almeida J, Fruhbeck G, Ribeiro R, Hu P (2022). Epigenome-wide DNA methylation and transcriptome profiling of localized and locally advanced prostate cancer: Uncovering new molecular markers. Genomics, 110474. https://doi.org/10.1016/j.ygeno.2022.110474
Lopez-Fernandez H, Duque P, Vazquez N, Fdez-Riverola F, Reboiro-Jato M, Vieira CP, Vieira J (2022) SEDA: A Desktop Tool Suite for FASTA Files Processing. IEEE/ACM Trans Comput Biol Bioinform 19(3):1850-1860. DOI: 10.1109/TCBB.2020.3040383
Loureiro, J.R.; Castro, A.F.; Figueiredo, A.S.; Silveira, I. Molecular Mechanisms in Pentanucleotide Repeat Diseases. (2022) Cells. 11(2):205. DOI: 10.3390/cells11020205
Marques C, Poças J, Gomes C, Faria-Ramos I, Reis CA, Vivès RR, Magalhães A, (2022) Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates Heparan Sulfate biosynthesis and shapes gastric cancer cell motility and invasion, J Biol Chem (2022). DOI: 10.1016/j.jbc.2022.102546
Matinha-Cardoso J, Coutinho F, Lima S, Eufrásio A, Carvalho AP, Oliva-Teles A, Bessa J, Tamagnini P, Serra CR, Oliveira P (2022) Novel protein carrier system based on cyanobacterial nano-sized extracellular vesicles for application in fish. Microbial Biotechnology, In press. DOI: 10.1111/1751-7915.14057
Mosteo L, Reis J, Rocha L, Lopes M, Duarte D (2022). Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells. Journal of visualized experiments: JoVE, (187), 10.3791/64248. https://doi.org/10.3791/64248
Neves JV, Barroso C, Carvalho P, Nunes M, Gonçalves JFM, Rodrigues PNS (2022). Characterization of erythroferrone in a teleost fish (Dicentrarchus labrax) with two functional hepcidin types: more than an erythroid regulator. Frontiers in Immunology 13:867630. https://doi.org/10.3389/fimmu.2022.867630
Nogueira-Rodrigues J, Leite SC, Pinto-Costa R, Sousa SC, Luz LL, Sintra MA, Oliveira R, Monteiro AC, Pinheiro GG, Vitorino MS, Silva JA, Simão S, Fernandes VE, Provazník J, Benes V, Cruz CD, Safronov BV, Magalhães A, Reis CA, Vieira J, Vieira CP, Tiscórnia G, Araújo IM, Sousa MM (2022) Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection. Developmental Cell 57:1–11 DOI: 10.1016/j.devcel.2021.12.008
Osswald, M., Barros-Carvalho, A., Carmo, A.M., Loyer, N., Gracio, P.C., Sunkel, C.E., Homem, C.C.F., Januschke, J., and Morais-de-Sa, E. (2022). aPKC regulates apical constriction to prevent tissue rupture in the Drosophila follicular epithelium. Curr Biol. DOI: 10.1016/j.cub.2022.08.063
Pereira JM, Xu S, Leong JM, Sousa S (2022) The Yin and Yang of Pneumolysin During Pneumococcal Infection. Front. Immunol. 13:878244. DOI: 10.3389/fimmu.2022.878244
Ribeiro R, Macedo JC, Costa M, Ustiyan V, Shindyapina AV, Tyshkovskiy A, Gomes RN, Castro JP, Kalin TV, Vasques-Nóvoa F, Nascimento DS, Gladyshev VN, Kalinichenko VV, Logarinho E (2022) In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan. Nature Aging 2:397-411. DOI: 10.1038/s43587-022-00209-9
Rodrigues PM, Sousa LG, Perrod C, Maceiras AR, Ferreirinha P, Pombinho R, Romera-Cárdenas G, Gomez-Lazaro M, Senkara M, Pistolic J, Cabanes D, Klein L, Saftig P, Alves NL (2022) LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development. Autophagy. DOI: 10.1080/15548627.2022.2074105
Silva-Carvalho R, Leão T, Bourbon AI, Gonçalves C, Pastrana LM, Parpot P, Amorim I, Tomás AM, Gama FM. (2022) Hyaluronic acid-amphotericin B nanocomplexes: a promising anti-leishmanial drug delivery system. Biomater Sci. 2022 Apr 12;10(8):1952-1967. doi: 10.1039/d1bm01769a. PMID: 35253814.
Silva-Carvalho R, Leão T, Gama FM, Tomás AM (2022). Covalent conjugation of amphotericin B to hyaluronic acid: an injectable water-soluble conjugate with reduced toxicity and anti-leishmanial potential. Biomacromolecules, 23(3), 1169-1182. DOI: 10.1021/acs.biomac.1c01451
Silva ML, Cá B, Osório NS, Rodrigues PNS, Maceiras AR, Saraiva M. Tuberculosis caused by Mycobacterium africanum: Knowns and unknowns. PLoS Pathog. 2022 May 26;18(5):e1010490. doi: 10.1371/journal.ppat.1010490. PMID: 35617217; PMCID: PMC9135246
2021
Barroso C, Carvalho P, Gonçalves JFM, Rodrigues PNS, Neves JV (2021). Antimicrobial Peptides: Identification of two Beta-Defensins in a Teleost Fish, the European Sea Bass (Dicentrarchus labrax). Pharmaceuticals 14(6): 566. https://doi.org/10.3390/ph14060566
Barroso C, Carvalho P, Nunes M, Gonçalves JFM, Rodrigues PNS, Neves JV (2021). The Era of Antimicrobial Peptides: use of hepcidins to prevent or treat bacterial infections and iron disorders. Frontiers in Immunology 12:754437. https://doi.org/10.3389/fimmu.2021.754437
Barroso-Vilares M, Macedo JC, Reis M, Warren JD, Compton D, Logarinho E. Small-molecule inhibition of aging-associated chromosomal instability delays cellular senescence. EMBO Rep. 2020 May 6;21(5):e49248. doi: 10.15252/embr.201949248.
Bento CM, Gomes MS, Silva T (2021) Evolution of Antibacterial Drug Screening Methods: Current Prospects for Mycobacteria. Microorganisms 9(12):2562. DOI: 10.3390/microorganisms9122562
Bezerra F, Niemietz C, Schmidt H, Zibert A, Guo S, Monia BP, Gonçalves P, Saraiva MJ, Almeida MR (2021) In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis. International journal of molecular sciences 22(17):9488. DOI: 10.3390/ijms22179488
Canedo, T., C. C. Portugal, R. Socodato, T. O. Almeida, A. F. Terceiro, J. Bravo, A. I. Silva, J. D. Magalhães, S. Guerra-Gomes, J. F. Oliveira, N. Sousa, A. Magalhães, J. B. Relvas, and T. Summavielle (2021). "Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine." Neuropsychopharmacology 46 (13):2358-2370. doi: 10.1038/s41386-021-01139-7
Cardoso A*, Martins AC*, Maceiras AR, Liu W, Castro I, Castro AG, Bandeira A, Di Santo JP, Cumano A, Li Y, Vieira P, Saraiva M. (2021). Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis. Cell Rep. 37(4):109887. DOI: 10.1016/j.celrep.2021.109887. *Equal contribution as first author
Cardoso D, Lima S, Matinha-Cardoso J, Tamagnini P, Oliveira P (2021). The Role of Outer Membrane Protein(s) Harboring SLH/OprB-Domains in Extracellular Vesicles' Production in Synechocystis sp. PCC 6803. Plants (Basel, Switzerland) 10(12):2757. DOI: 10.3390/plants1012275
Cardoso MS, Santos RF, Almeida S, Sá M, Pérez-Cabezas B, Oliveira L, Tavares J, Carmo AM (2021) Physical interactions with bacteria and protozoan parasites establish the scavenger receptor SSC4D as a broad-spectrum pattern recognition receptor. Front. Immunol. 12:760770. DOI: 10.3389/fimmu.2021.760770
Cotrina EY, Santos LM, Rivas J, Blasi D, Leite JP, Liz MA, Busquets MA, Planas A, Prohens R, Gimeno A, Jiménez-Barbero J, Gales L, Llop J, Quintana J, Cardoso I, Gemma A (2021) Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease. European Journal of Medicinal Chemistry 226:113847. DOI: 10.1016/j.ejmech.2021.113847
De-Castro ARG*, Rodrigues DRM*, De-Castro MJG, Vieira N, Vieira C, Carvalho AX, Gassmann R, Abreu CM, Dantas TJ. WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing. Journal of Cell Biology (2021). DOI: https://doi.org/10.1083/jcb.202010178
Duque M, Amorim JP, Bessa J* (2021) Ptf1a function and transcriptional cis-regulation, a cornerstone in vertebrate pancreas development. FEBS J. 289(17):5121-5136. DOI: 10.1111/febs.16075
Eira J, Magalhães J, Macedo N, Pero ME, Misgeld T, Sousa MM, Bartolini F, Liz MA (2021).Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation. Frontiers in Cell and Developmental Biology. DOI:10.3389/fcell.2021.747699
Figueiredo, J., Mercadillo, F., Melo, S., Barroso, A., Goncalves, M., Diaz-Tasende, J., Carneiro, P., Robles, L., Colina, F., Ibarrola, C., et al. (2021). Germline CDH1 G212E Missense Variant: Combining Clinical, In Vitro and In Vivo Strategies to Unravel Disease Burden. Cancers (Basel) 13. DOI: 10.3390/cancers13174359
Gião T, Saavedra J, Vieira JR, Pinto MT, Arsequell G, Cardoso I (2021) Neuroprotection in early stages of Alzheimer's disease is promoted by transthyretin angiogenic properties. Alzheimers Res Ther. 13(1):143. DOI: 10.1186/s13195-021-00883-8
Gomes RN, Manuel F, Nascimento DS (2021) The bright side of fibroblasts: molecular signature and regenerative cues in major organs. NPJ Regen Med 6(1):43. DOI: 10.1038/s41536-021-00153-z
Laundos TL, Vasques-Nóvoa F, Gomes RN, Sampaio-Pinto V, Cruz P, Cruz H, Santos JM, Barcia RN, Pinto-do-Ó P, Nascimento DS (2021) Consistent Long-Term Therapeutic Efficacy of Human Umbilical Cord Matrix-Derived Mesenchymal Stromal Cells After Myocardial Infarction Despite Individual Differences and Transient Engraftment. Front. Cell Dev. Biol 9:624601. DOI: 10.3389/fcell.2021.624601
Leite J, Lete M, Fowler S, Gimeno A, Rocha J, Sousa S, Webster C, Jiménez-Barbero J, Gales L (2021) Aβ31-35 decreases Neprilysin-mediated Alzheimer’s Amyloid-β peptide degradation. ACS Chemical Neuroscience 12(19):3708-3718. DOI: 10.1021/acschemneuro.1c00432
Magalhães J, Eira J, Liz MA (2021). The role of transthyretin in cell biology: impact on human pathophysiology. Cellular and Molecular Life Sciences. DOI:10.1007/s00018-021-03899-3
Marques C, Reis CA, Vivès RR, Magalhães A (2021) Heparan Sulfate Biosynthesis and Sulfation Profiles as Modulators of Cancer Signalling and Progression. Front Oncol 11:778752. DOI: 10.3389/fonc.2021.778752
Moreira J, Costelha S, Saraiva, M, Saraiva MJ (2021) The expression of chemokines is downregulated in a pre-clinical model of TTR V30M amyloidosis. Frontiers in Immunology 12:650269. DOI: 10.3389/fimmu.2021.650269
Nagaraj S, Want A, Laskowska-Kaszub K, Fesiuk A, Vaz S, Logarinho E, Wojda U. Candidate Alzheimer's Disease Biomarker miR-483-5p Lowers TAU Phosphorylation by Direct ERK1/2 Repression. Int J Mol Sci. 2021 Apr 1;22(7):3653. doi: 10.3390/ijms22073653.
Neves JV, Gomes AC, Costa DM, Barroso C, Vaulont S, Cordeiro da Silva A, Tavares J, Rodrigues PNS (2021). A role for hepcidin in the anemia caused by Trypanosoma brucei infection. Haematologica 106(3): 806-818. http://dx.doi.org/10.3324/haematol.2019.227728
Sara Vaz, Fábio J. Ferreira, Joana C. Macedo, Gil Leor, Uri Ben-David, José Bessa & Elsa Logarinho. (2021). FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation. Cell Death & Disease, 12. DOI: 10.1038/s41419-021-03822-5
Santos, M., Pacheco, C.C., Yao, L., Hudson, E.P., Tamagnini, P. (2021) CRISPRi as a tool to repress multiple copies of extracellular polymeric substances (EPS)-related genes in the cyanobacterium Synechocystis sp. PCC 6803. Life 11:1198. doi:10.3390/life11111198
Santos, M., Pereira, S.B., Flores, C., Príncipe, C., Couto, N., Karunakaran, E., Cravo, S.M., Oliveira, P. and Tamagnini, P. (2021) Absence of KpsM (Slr0977) impairs the secretion of extracellular polymeric substances (EPS) and impacts carbon fluxes in Synechocystis sp. PCC 6803. mSphere 6:00003-21. DOI:10.1128/mSphere.00003-21
Silvério, D, Gonçalves, R, Appelberg, R, Saraiva, M (2021) Advances on the Role and Applications of Interleukin-1 in Tuberculosis. mBio 12(6): e03134-21. DOI: 10/1128/mBio.03134-21
2020
Amorim JP, Bordeira-Carriço R, Gali-Macedo A, Perrod C and Bessa J* (2020) CRISPR/Cas9 mediated genomic deletions protocol in zebrafish. STAR Protocols 1(3):100208. DOI: 10.1016/j.xpro.2020.100208
Amorim JP, Gali-Macedo A, Marcelino H, Bordeira-Carriço R, Naranjo S, Rivero-Gil S, Teixeira J, Galhardo M, Marques J and Bessa J* (2020) A conserved notochord enhancer controls pancreas development in vertebrates. Cell Reports 32(1):107862. DOI: 10.1016/j.celrep.2020.107862
Barroso C, Carvalho P, Carvalho C, Santarém N, Gonçalves JFM, Rodrigues PNS, Neves JV (2020). The Diverse Piscidin Repertoire of the European Sea Bass (Dicentrarchus labrax): Molecular Characterization and Antimicrobial Activities. International Journal of Molecular Sciences 21(13):4613. http://dx.doi.org/10.3390/ijms21134613
Bezerra F, Saraiva MJ, Almeida MR (2020) Modulation of the Mechanisms Driving Transthyretin Amyloidosis. Frontiers in molecular neuroscience, 13:592644. DOI: 10.3389/fnmol.2020.592644
Carmo AM, Henriques SN (2020) Cell activation and signaling in lymphocytes, in JV Silva, MJ Freitas, M Fardilha (Eds.), Tissue-Specific Cell Signaling, Springer Nature pp133-161. ISBN: 978-3-030-44435-8.
Castro, A.F.; Loureiro, J.R.; Bessa, J.; Silveira, I. Antisense Transcription across Nucleotide Repeat Expansions in Neurodegenerative and Neuromuscular Diseases: Progress and Mysteries. (2020) Genes. 11(12), 1418. https://doi.org/10.3390/genes11121418
Cotrina ElY, Oliveira A, Leite JP, Llop J, Gales L, Quintana J, Cardoso I, Gemma A (2020) Repurposing benzbromarone for Familial Amyloid Polyneuropathy: a new transthyretin tetramer stabilizer. International Journal of Molecular Siences 21(9): 7166. DOI: 10.3390/ijms21197166
Cunha-Silva, S., Osswald, M., Goeman, J., Barbosa, J., Santos, L.M., Resende, P., Bange, T., Ferrás, C., Sunkel, C.E., Conde, C. (2020). Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation. Journal of Cell Biology, 219(3). https://doi.org/10.1083/jcb.201906039
Eufrásio A, Perrod C, Ferreira FJ, Duque M, Galhardo M and Bessa J* (2020) In vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes Associated SNPs. Diabetes 69(12):2794-2805. DOI: 10.2337/db19-1049
Fonseca, KL, Maceiras, AR, Matos, R, Simoes-Costa, L, Sousa, J, Cá, B, Barros, L, Fernandes, AI, Mereiter, S, Reis, R, Gomes, J, Tapia, G, Rodríguez-Martínez, P, Martín-Céspedes, M, Vashakidze, S, Gogishvili, S, Nikolaishvili, K, Appelberg, R, Gärtner, F, Rodrigues, PNS, Vilaplana, C, Reis, CA, Magalhães, A, Saraiva, M. (2020) Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils. Mucosal Immunology 13:836-848. DOI:10.1038/s41385-020-0277-7
Gonçalves CF, Lima S, Oliveira P (2020) Product export in cyanobacteria. p. 369-406, in “Cyanobacteria biotechnology”, Wiley Advanced Biotechnology series, edited by Paul Hudson (Editor), WILEY‐VCH GmbH, (ISBN-10: 3527347143, ISBN-13: 978-3527347148). DOI: 10.1002/9783527824908.ch12
Lima S, Matinha-Cardoso J, Tamagnini P, Oliveira P (2020) Extracellular Vesicles: An Overlooked Secretion System in Cyanobacteria. Life, 10(8):129. DOI: 10.3390/life10080129
Mendes R, Figueira F, Leite J, Gales L*, Paz F* (2020) Metal-Organic Frameworks: a Future Toolbox for Biomedicine? Chemical Society Reviews 49:9121-9153. DOI: 10.1039/d0cs00883d
Moreira-Teixeira, L, Tabone, O, Graham, CM, Singhania, A, Stavropoulos, E, Redford, PS, Chakravarty, P, Priestnall, SL, Suarez-Bonnet, A, Herbert, E, Mayer-Barber, KD, Sher, A, Fonseca, KL, Sousa J, Cá B, Verma, R, Haldar, P, Saraiva, M, O'Garra, A. (2020) Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis. Nature Immunology 21:464-476. DOI:10.1038/s41590-020-0610-z
Niemietz C, Bezerra F, Almeida MR, Guo S, Monia BP, Saraiva MJ, Schütz P, Schmidt HH, Zibert A (2020) SERPINA1 modulates expression of amyloidogenic transthyretin. Experimental cell research 395(2):112217. DOI: 10.1016/j.yexcr.2020.112217
Oliveira da Silva, MI, Lopes, CS, Liz, MA (2020) Transthyretin interacts with actin regulators in a Drosophila model of familial amyloid polyneuropathy. Scientific Reports 10:13596. DOI: 10.1038/s41598-020-70377-4
Oliveira da Silva, MI, Liz, MA (2020) Linking alpha-synuclein to the actin cytoskeleton: consequences to neuronal function. Frontiers in Cell and Developmental Biology. 8:787. DOI: 10.3389/fcell.2020.00787
Pires, SDS.*; Oliveira, R*; Moradas-Ferreira, P, Mendes, MV (2020) The onset of tacrolimus biosynthesis in Streptomyces tsukubaensis is dependent on the intracellular redox status. Antibiotics 9:703. DOI:10.3390/antibiotics9100703 *These authors contributed equally to this work.
Sousa, J*, Cá, B*, Maceiras, AR, Simões-Costa, L, Fonseca, KL, Fernandes, AI, Ramos, A, Carvalho, T, Barros, L, Magalhães, C, Chiner-Oms, Á, Machado, H, Veiga, MI, Singh, A, Pereira, R, Amorim, A, Vieira, J, Vieira, CP, Bhatt, A, Rodrigues, F, Rodrigues, PNS, Gagneux, S, Castro, AG, Guimarães, JT, Bastos, HN, Osório, NS, Comas, I, Saraiva, M. (2020) Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production. Nature Communications 11:1949. doi:10.1038/s41467-020-15832-6 *These authors contributed equally to this work.
Ventura, G., Moreira, S., Barros-Carvalho, A., Osswald, M., and Morais-de-Sa, E. (2020). Lgl cortical dynamics are independent of binding to the Scrib-Dlg complex but require Dlg-dependent restriction of aPKC. Development 147. DOI: 10.1242/dev.186593
2019
Barroso-Vilares, M., and Logarinho, E. (2019), Chromosomal instability and pro-inflammatory response in aging. Mechanisms of ageing and development, 182: 111118. https://doi.org/10.1016/j.mad.2019.111118 (Review)
Bezerra F, Simões C, Beirão JM, Saraiva MJ, Brito R, Almeida MR (2019) Targeting transthyretin amyloidosis in the eye with next-generation stabilizers: AT40 displays potent TTR stabilization in the human vitreous. Amyloid: the international journal of experimental and clinical investigation: the official journal of the International Society of Amyloidosis 26(sup1):73-74. DOI: 10.1080/13506129.2019.1583193
Brito, C.; Mesquita, F.S.; Bleck, C.K.E.; Sellers, J.R.; Cabanes, D.; Sousa, S. Perfringolysin O-Induced Plasma Membrane Pores Trigger Actomyosin Remodeling and Endoplasmic Reticulum Redistribution. Toxins 2019, 11(7), 419. https://doi.org/10.3390/toxins11070419
Brito, C.; Cabanes, D.; Mesquita, F.S.; Sousa, S. Mechanisms protecting host cells against bacterial pore-forming toxins. Cell. Mol. Life Sci. 2019, 76, 1319–1339. Review. https://doi.org/10.1007/s00018-018-2992-8
Cá, Baltazar; Fonseca, Kaori L.; Sousa, Jeremy; Maceiras, Ana Raquel; Machado, Dia-na; Sanca, Lilica; Rabna, Paulo; et al. 2019. "Experimental Evidence for Limited in vivo Virulence of Mycobacterium africanum". Frontiers in Microbiology 10. http://dx.doi.org/10.3389/fmicb.2019.02102
Cereija, T.B., Alarico, S., Lourenço, E.C., Manso, J.A., Ventura, M. R., Empadinhas, N., Macedo-Ribeiro, S., Pereira, P.J.B. (2019), The structural characterization of a glucosyl-glycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation. IUCrJ, 6(Pt 4):572-585. https://doi.org/10.1107/S2052252519005372
Flores, C., Lima, R. T., Adessi, A., Sousa, A., Pereira, S. B., Granja, P. L., De Philippis, R., Soares, P., & Tamagnini, P. (2019), Characterization and antitumor activity of the extracellular carbohydrate polymer from the cyanobacterium Synechocystis ΔsigF mutant. International Journal of Biological Macromolecules, 136: 1219-1227. https://doi.org/10.1016/j.ijbiomac.2019.06.152
Flores, C., & Tamagnini, P. (2019), Looking Outwards: Isolation of Cyanobacterial Re-leased Carbohydrate Polymers and Proteins. JoVE - J. Vis. Exp., 147: e59590. https://doi.org/10.3791/59590
Flores, C., Santos, M., Pereira, S. B., Mota, R., Rossi, F., De Philippis, R., Couto, N., Karunakaran, E., Wright, P. C., Oliveira, P., & Tamagnini, P. (2019), The alternative sigma fac-tor SigF is a key player in the control of secretion mechanisms in Synechocystis sp. PCC 6803. Environmental Microbiology, 21: 343–359. https://doi.org/10.1111/1462-2920.14465
Freitas, RF., Basto, A., Almeida, SCP., Santos, RF., Gonçalves, CM., Corria-Osorio, J., Carvalho, T., Carmo, AM., Oliveira, VG., Leon, K., Graça, L. (2019). Modulation of CD4 T cell function via CD6-targeting. EBioMedicine. 2019 Aug 14. pii: S2352-3964(19)30524-9. DOI: https://doi.org/10.1016/j.ebiom.2019.08.008
Ghazaryan N., Movsisyan N., Macedo J.C., Vaz S., Ayvazyan N., Pardo L., Logarinho E. (2019), The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model. Invest New Drugs. https://doi.org/10.1007/s10637-019-00734-2 [Epub ahead of print]
Gonçalves, C.F., Lima, S., Tamagnini, P., and Oliveira, P. (2019). Cyanobacterial secretion systems: understanding fundamental mechanisms towards technological applications. p. 359-381, in "Cyanobacteria: from basic science to applications" (ISBN: 9780128146675), eds. A.K. Mishra, D.N. Tiwari, A.N. Rai. Academic Press, Elsevier, London, UK.
Leite, J. P.; Rodrigues, D.; Ferreira, S.; Figueira, F.; Almeida Paz, F. A.; Gales, L., Mesoporous Metal-Organic Frameworks as Effective Nucleating Agents in Protein Crystallography. Crystal Growth & Design 2019, 19 (3), 1610-1615. https://doi.org/10.1021/acs.cgd.8b01444
Leite, J. P.; Gales, L., Alzheimer's Aβ1-40 peptide degradation by thermolysin: evidence of inhibition by a C-terminal Aβ product. FEBS Letters 2019, 593 (1), 128-137. https://doi.org/10.1002/1873-3468.13285
Leite, J. P., Gales, L. (2019), Fluorescence properties of the amyloid indicator dye thioflavin T in constrained environments. Dyes and Pigments, 160(64-70). https://doi.org/10.1016/j.dyepig.2018.07.049
Loureiro, J. R., Oliveira, C. L., Mota, C., Castro, A. F., Costa, C., Loureiro, J. L., Coutinho, P., Martins, S., Sequeiros, J., Silveira, I. (2019). Mutational Mechanism for DAB1 (ATTTC)n insertion in SCA37: ATTTT Repeat Lengthening and Nucleotide substitution. Human Mutation, 40:404-412. https://doi.org/10.1002/humu.23704
Malheiro AR, Correia B, Ferreira da Silva T, Bessa-Neto D, Van Veldhoven PP, Brites P. (2019) “Leukodystrophy caused by plasmalogen deficiency rescued by glyceryl 1-myristyl ether treatment” Brain Pathol, Jan 22. https://doi.org/10.1111/bpa.12710
Moreira, S., Osswald, M., Ventura, G., Gonçalves, M., Sunkel, C.E., and Morais-de-Sá, E. (2019). PP1-Mediated Dephosphorylation of Lgl Controls Apical-basal Polarity. Cell Rep. 26, 293-301.e7. https://doi.org/10.1016/j.celrep.2018.12.060
Moura, M., Conde, C. (2019), Phosphatases in Mitosis: Roles and regulation. Biomolecules 9 (2), 55 (Review)
Oliveira M.S., Freitas J., Pinto P., Jesus A., Tavares J., Pinho M., Lopes C., Conde C., Sunkel C. and Moreira A. (2019), Cell Cycle Kinase Polo Is Controlled by a Widespread 3’ Untranslated Region Regulatory Sequence in Drosophila melanogaster. Molecular and Cell Biology. https://doi.org/10.1128/MCB.00581-18
Pereira SB, Sousa A, Santos M, Araújo M, Serôdio F, Granja PL, Tamagnini, P. (2019) Strategies to obtain designer polymers based on cyanobacterial extracelular polymeric substances (EPS). International Journal of Molecular Sciences 20:5693. DOI:10.3390/ijms20225693
Pinho, M., Macedo, J.C., Logarinho, E., Pereira, P.S. (2019). NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging. Mol Cell Biol. 2019 May 28;39(12). https://doi.org/10.1128/MCB.00099-19
Rocha, R., Teixeira-Duarte, C. M., Jorge, J. M. P., & Morais-Cabral, J. H. (2019). Characterization of the molecular properties of KtrC, a second RCK domain that regulates a Ktr channel in Bacillus subtilis. J Struct Biol, 205(3), 34-43. https://doi.org/10.1016/j.jsb.2019.02.002
Santos, RF., Oliveira, L., Brown, MH., Carmo, AM. (2019). Domain-specific CD6 monoclonal antibodies identify CD6 isoforms generated by alternative splicing. Immunology. 2019 Aug;157(4):296-303. https://doi.org/10.1111/imm.13087
Shukla S., Milewski D., Pradhan A., Rama N., Rice K., Le T., Flick M.J., Vaz S., Zhao X., Setchell K.D., Logarinho E., Kalinichenko V.V., Kalin T.V. (2019), The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear β-Catenin. Mol Cancer Ther;18:1217–29. https://doi.org/10.1158/1535-7163.MCT-18-0709
Simões C, Almeida ZL, Cardoso AL, Bezerra F, Almeida MR, Beirão J, Pinho E Melo T, Saraiva MJ, Brito R (2019) Lead optimization of resilient next-generation transthyretin stabilizers for multiple target-product profiles: approaching the CNS. Amyloid: the international journal of experimental and clinical investigation: the official journal of the International Society of Amyloidosis, 26(sup1):77–78. DOI: 10.1080/13506129.2019.1583195
Teixeira-Duarte CM, Fonseca F, Morais-Cabral JH. "Activation of a Nucleotide-Dependent RCK Domain Requires Binding of a Cation Cofactor to a Conserved Site.” eLife (2019), 8:e50661 DOI: 10.7554/eLife.50661
2018
Costa, A. R., Pinto-Costa, R., Sousa, S. C., Sousa, M. M. (2018), The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swell-ing. Front. Mol. Neurosci., 11: 319. https://doi.org/10.3389/fnmol.2018.00319 (Review)
De Munter S, Bamps D, Malheiro AR, Kumar Baboota R, Brites P, Baes M. (2018) “Autonomous Purkinje cell axonal dystrophy causes ataxia in peroxisomal multifunctional protein-2 deficiency” Brain Pathol, Sep;28(5):631-643. https://doi.org/10.1111/bpa.12586
Gonçalves, CM., Henriques, SH., Santos, RF., Carmo, AM. (2018). CD6, a Rheostat-Type Signalosome That Tunes T Cell Activation. Front. Immunol. 2018 Dec; 18;9:2994. https://doi.org/10.3389/fimmu.2018.02994
Leite, J. P. and Gales, L. (2018), Alzheimer's Aβ1-40 peptide degradation by thermolysin: evidence of inhibition by a C‐terminal Aβ product. FEBS Lett. https://doi.org/10.1002/1873-3468.13285
Loureiro, J. R., Oliveira, C. L., Sequeiros, J., Silveira, I. (2018), A repeat-primed PCR as-say for pentanucleotide repeat alleles in spinocerebellar ataxia type 37. J. Hum. Genet., 63:981-987. https://doi.org/10.1038/s10038-018-0474-3
Macedo, J. C., Vaz, S., Bakker, B., Ribeiro, R., Bakker, P. L., Escandell, J. M., Ferreira, M. G., Medema, R., Foijer, F., Logarinho, E. (2018), FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence. Nat. Commun., 19;9(1):2834. https://doi.org/10.1093/cercor/bhx023
Nascimento, A. I., Mar, F. M., Sousa, M. M. (2018), The intriguing nature of dorsal root ganglion neurons: Linking structure with polarity and function. Prog. Neurobiol., 168:86-103. https://doi.org/10.1016/j.pneurobio.2018.05.002
Novais-Cruz, M., Abad, M. A., van Ijcken, W. F. J., Galjart, N., Jeyaprakash, A. A., Maiato, H., Ferrás, C. (2018), Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription. eLife, 7: e36898. https://doi.org/10.7554/eLife.36898
Oliveira, L, Santos, RF, Carmo, AM (2018) CD6, in S. Choi (Ed.), Encyclopedia of Signalling Molecules, 2nd Edn., Springer, pp937-943.
Pereira, S. B.*, Santos, M.*, Leite, J. P., Flores, C., Eisfeld, C., Buttel, Z., Mota, R., Rossi, F., De Philippis, R., Cabral, J. M. And Tamagnini, P. (2018), The role of the tyrosine ki-nase Wzc (Sll0923) and the phosphatase Wzb (Slr0328) in the production of extracellular polymeric substances (EPS) by Synechocystis PCC 6803. Microbiology-Open. https://doi.org/10.1002/mbo3.753 *These authors contributed equally to this work.
Sousa J, Saraiva M. Paradigm changing evidence that alter tuberculosis perception and detection: Focus on latency. Infect Genet Evol. (2019),72:78-85. DOI: 10.1016/j.meegid.2018.12.019 Epub 2018 Dec 18.PMID: 30576838
2017
Cereija, T. B., Alarico, S., Empadinhas, N., Pereira, P. J. B. (2017), Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase. Acta Crystallogr. F Struct. Biol. Commun., 73(Pt 9):536-540. https://doi.org/10.1107/S2053230X17012419
Fixman, B. B., Babcock, I. W., Minamide, L. S., Shaw, A. E., da Silva, M. I. O., Runyan, A. M., ... & Bamburg, J. R. (2017). Modified Roller Tube Method for Precisely Localized and Repetitive Intermittent Imaging During Long-term Culture of Brain Slices in an Enclosed System. JoVE (Journal of Visualized Experiments), (130), e56436. https://doi.org/10.3791/56436
Fonseca, K.L., Rodrigues, P. N. S., Olsson, I. A. S., Saraiva, M. (2017), Experimental study of tuberculosis: From animal models to complex cell systems and organoids. PloS Pathog. 13(8):e1006421. https://doi.org/10.1371/journal.ppat.1006421
Franquinho. F., Nogueira-Rodrigues, J., Duarte. J.M., Esteves, S.S., Carter-Su, C., Mona-co A.P., Molnár, Z., Velayos-Baeza, A., Brites, P., Sousa, M.M. (2017) The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling. Cereb Cortex. 1;27(3):1732-1747. https://doi.org/10.1093/cercor/bhx023
Liu, X., Freitas, J., Zheng, D., Oliveira, M. S., Hoque, M., Martins, T., Henriques, T., Tian, B., and Moreira, A. (2017), Transcription elongation rate has a tissue-specific impact on alternative cleavage and 3 polyadenylation in Drosophila melanogaster. RNA, 23(12), 1807-1816. https://doi.org/10.1261/rna.062661.117
Macedo, J. C., Vaz, S., Logarinho, E. (2017), Mitotic dysfunction associated with aging hallmarks. Adv. Exp. Med. Biol., 1002:153-188. https://doi.org/10.1007/978-3-319-57127-0_7 (Book Chapter)
Maiato, H., Gomes, A. M., Sousa, F., Barisic, M. (2017), Mechanisms of chromosome congression during mitosis. Biology (Basel), 6(1). pii: E13. https://doi.org/10.3390/biology6010013 (Review)
Meireles, C., Ribeiro, A. R., Pinto, R. D., Leitão, C., Rodrigues, P. M. and Alves, N. L. (2017), Thymic crosstalk restrains the pool of cortical thymic epithelial cells with progenitor properties. Eur. J. Immunol., 47: 958-969. https://doi.org/10.1002/eji.201746922
Mesquita, F.S.; Brito, C.; Cabanes, D.; Sousa, S. Control of cytoskeletal dynamics during cellular responses to pore forming toxins. Commun. Integr. Biol. 2017, 10, e1349582. https://doi.org/10.1080/19420889.2017.1349582
Mesquita, F.S.; Brito, C.; Mazon Moya, M.J.; Pinheiro, J.C.; Mostowy, S.; Cabanes, D.; Sousa, S. Endoplasmic reticulum chaperone Gp96 controls actomyosin dynamics and protects against pore-forming toxins. EMBO Rep. 2017, 18, 303–318. https://doi.org/10.15252/embr.201642833
Moura, M.; Osswald, M.; Leça, N.; Barbosa, J.; Pereira, A.J.; Maiato, H.; Sunkel, C.E.; Conde, C.. "Protein phosphatase 1 inactivates Mps1 to ensure efficient spindle assembly checkpoint silencing". eLife 6 (2017)
Seixas, A. I., Loureiro, J. R., Costa, C., Ordóñez-Ugalde, A., Marcelino, H., Oliveira, C. L., Loureiro, J. L., Dhingra, A., Brandão, E., Cruz, V. T., Timóteo, A., Quintáns, B., Rouleau, G. A., Rizzu, P., Carracedo, A., Bessa, J., Heutink, P., Sequeiros, J., Sobrido, M. J., Coutinho, P., Silveira, I. (2017), A Pentanucleotide ATTTC Repeat Insertion in the Non-coding Re-gion of DAB1, Mapping to SCA37, Causes Spinocerebellar Ataxia. Am. J. Hum. Genet., 101(1):87-103. https://doi.org/10.1016/j.ajhg.2017.06.007
Shinde AB, Baboota RK, Denis S, Loizides-Mangold U, Peeters A, Espeel M, Malheiro AR, Riezman H, Vinckier S, Vaz FM, Brites P, Ferdinandusse S, Van Veldhoven PP, Baes M. (2017) “Mitochondrial disruption in peroxisome deficient cells is hepatocyte selective but is not mediated by common hepatic peroxisomal metabolites.” Mitochondrion. 2017 Sep 1. pii: S1567-7249(17)30218-0. https://doi.org/10.1016/j.mito.2017.08.013
Silva, C. S., Eira, J., Ribeiro, C. A., Oliveira, Â., Sousa, M. M., Cardoso, I., Liz, M. A. (2017), Transthyretin neuroprotection in Alzheimer's disease is dependent on proteolysis. Neurobiol. Aging, 59:10-14. https://doi.org/10.1016/j.neurobiolaging.2017.07.002
Teixeira, C., Costelha, S., Martins, H. S., Teixeira, A., Saraiva, M. J. (2017), Doxycycline-tauroursodeoxycholic acid treatment: effects in the heart of a transthyretin V30M transgenic mouse model. Amyloid, 24(sup1):80. https://doi.org/10.1080/13506129.2016.1277695
2016
Bessa-Pereira, C, Bocková, M, Santos, RF, Santos, AM, Martins de Araújo, M, Oliveira, L, Homola, J, Carmo, AM (2016) The scavenger receptor SSc5D physically interacts with bacteria through the SRCR-containing N-terminal domain. Frontiers in Immunology 7:416. DOI:10.3389/fimmu.2016.00416
De Munter S, Verheijden S, Vanderstuyft E, Malheiro AR, Brites P, Gall D, Schiffmann SN, Baes M. (2016) “Early-onset Purkinje cell dysfunction underlies cerebellar ataxia in peroxisomal multifunctional protein-2 deficiency”, Neurobiol Dis, Oct;94:157-68. https://doi.org/10.1016/j.nbd.2016.06.012
Leite, S. C., Sampaio, P., Sousa, V. F., Nogueira-Rodrigues, J., Pinto-Costa, R., Peters, L.L., Brites, P., Sousa, M. M. (2016), The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter. Cell Rep., 15(3):490-498. https://doi.org/10.1016/j.celrep.2016.03.047
Loureiro, J. R., Oliveira, C. L., Silveira, I. (2016), Unstable repeat expansions in neurodegenerative diseases: nucleocytoplasmic transport emerges on the scene. Neurobiol. Aging, 39:174-183. https://doi.org/10.1016/j.neurobiolaging.2015.12.007 (Review)
Moreira, S., and Morais-de-Sá, E. (2016). Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons. BioArchitecture 6, 29–38. https://doi.org/10.1080/19490992.2016.1149290
Moreira-Teixeira L, Sousa J, McNab FW, Torrado E, Cardoso F, Machado H, Castro F, Cardoso V, Gaifem J, Wu X, Appelberg R, Castro AG, O'Garra A, Saraiva M. Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling. J Immunol. (2016),15;197(12):4714-4726. DOI: 10.4049/jimmunol.1600584 PMID:27849167
Santos, RF, Oliveira, L, Carmo, AM (2016) Tuning T cell activation: the function of CD6 at the immunological synapse and in T cell responses. Current Drug Targets 17:630-639. DOI:10.2174/1389450116666150531152439
Szollosi, A., Vieira-Pires, R. S., Teixeira-Duarte, C. M., Rocha, R., & Morais-Cabral, J. H. (2016). Dissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the KtrAB K+ Transporter. PLoS Biol, 14(1), e1002356. https://doi.org/10.1371/journal.pbio.1002356
Teixeira, C. A., Almeida, M. R., Saraiva, M.J. (2016), Impairment of autophagy by TTR V30M aggregates: in vivo reversal by TUDCA and curcumin. Clin. Sci. (Lond), 130(18):1665-75. https://doi.org/10.1042/CS20160075
2015
Malheiro AR, Ferreira da Silva T, and Brites P. (2015) “Plasmalogens and fatty alcohols in Rhizomelic Chondrodysplasia Punctata and Sjogren-Larsson syndrome”, J Inherit Metab Dis, Jan;38(1):111-21. https://doi.org/10.1007/s10545-014-9795-3
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