2022

Alves S, Pereira JM, Mayer RL, Gonçalves ADA, Impens F, Cabanes D, Sousa S (2022). Cells Responding to Closely Related Cholesterol-Dependent Cytolysins Release Extracellular Vesicles with a Common Proteomic Content Including Membrane Repair Proteins. Toxins, 15(1), 4. https://doi.org/10.3390/toxins15010004

Barros-Carvalho, A., and Morais-de-Sa, E. (2022). Balancing cell polarity PARts through dephosphorylation. J Cell Biol 221. DOI: 10.1083/jcb.202208008

Biller SJ, Muñoz-Marín MdC, LIMA S, Matinha-Cardoso J, Tamagnini P, Oliveira P (2022) Isolation and Characterization of Cyanobacterial Extracellular Vesicles. J. Vis. Exp. (180): e63481 DOI: 10.3791/63481

Bordeira-Carriço R*, Teixeira J*, Duque M*, Galhardo M, Ribeiro D, Dominguez-Acemel R, Firbas PN, Tena JJ, Eufrasio A, Marques J, Ferreira FJ, Freitas T, Carneiro F, Goméz-Skarmeta J-L, Bessa J (2022) Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers. Nat Commun 13:1945. DOI: 10.1038/s41467-022-29551-7
*Equal contribution as first author

Costa AC, Sousa MM (2022) The Role of Spastin in Axon Biology. Front Cell Dev Biol 10:934522. DOI: 10.3389/fcell.2022.934522

Duque P, Vieira CP, Bastos B, Vieira J (2022) The evolution of vitamin C biosynthesis and transport in animals. BMC Ecol Evol 22(1):84. DOI: 10.1186/s12862-022-02040-7

Duque P, Vieira CP, Vieira J (2022). Advances in Novel Animal Vitamin C Biosynthesis Pathways and the Role of Prokaryote-Based Inferences to Understand Their Origin. Genes, 13(10), 1917. https://doi.org/10.3390/genes13101917

Ferreira JM, Jorge S, Félix L, Morello GM, Olsson IAS, Valentim AM (2022). Behavioural Aversion and Cortisol Level Assessment When Adult Zebrafish Are Exposed to Different Anaesthetics. Biology, 11(10), 1433.

Figueiredo, J., Ferreira, R.M., Xu, H., Goncalves, M., Barros-Carvalho, A., Cravo, J., Maia, A.F., Carneiro, P., Figueiredo, C., Smith, M.L., et al. (2022). Integrin beta1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells. Gastric Cancer 25, 124-137. DOI: 10.1007/s10120-021-01239-9

Freitas IL, Teixeira A, Loureiro I, Lisboa J, Saraiva A, dos Santos NMS, do Vale A (2022) Susceptibility of Sea Bream (Sparus aurata) to AIP56, an AB-Type Toxin Secreted by Photobacterium damselae subsp. piscicida. Toxins 14:119. DOI: 10.3390/toxins14020119

Gião T, Teixeira T, Almeida MR, Cardoso I (2022) Choroid Plexus in Alzheimer's Disease-The Current State of Knowledge. Biomedicines 10(2):224. DOI: 10.3390/biomedicines10020224

Gomes AM, Orr B, Novais-Cruz M, De Sousa F, Monteiro JM, Lemos C, Ferrás C, Maiato H (2022). Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells, Current Biology, 32, 4240–4254

Henriques SN, Oliveira L, Santos RF, Carmo AM (2022). CD6-mediated inhibition of T cell activation via modulation of Ras. Cell Commun Signal, 20(1), 184. https://doi.org/10.1186/s12964-022-00998-x

Leite AC, Martins TS, Campos A, Costa V, Pereira C (2022). Phosphoregulation of the ATP synthase beta subunit stimulates mitochondrial activity for G2/M progression, Advances in Biological Regulation, 85:100905

Lima S, Matinha-Cardoso J, Giner-Lamia J, Couto N, Pacheco CC, Florencio F J, Wright PC, Tamagnini P, Oliveira P (2022) Extracellular vesicles as an alternative copper-secretion mechanism in bacteria. Journal of Hazardous Materials 431:128594. DOI: 10.1016/j.jhazmat.2022.128594

Liu Q, Reed M, Zhu H, Cheng Y, Almeida J, Fruhbeck G, Ribeiro R, Hu P (2022). Epigenome-wide DNA methylation and transcriptome profiling of localized and locally advanced prostate cancer: Uncovering new molecular markers. Genomics, 110474.  https://doi.org/10.1016/j.ygeno.2022.110474

Lopez-Fernandez H, Duque P, Vazquez N, Fdez-Riverola F, Reboiro-Jato M, Vieira CP, Vieira J (2022) SEDA: A Desktop Tool Suite for FASTA Files Processing. IEEE/ACM Trans Comput Biol Bioinform 19(3):1850-1860. DOI: 10.1109/TCBB.2020.3040383

Loureiro, J.R.; Castro, A.F.; Figueiredo, A.S.; Silveira, I. Molecular Mechanisms in Pentanucleotide Repeat Diseases. (2022) Cells. 11(2):205. DOI: 10.3390/cells11020205

Marques C, Poças J, Gomes C, Faria-Ramos I, Reis CA, Vivès RR, Magalhães A, (2022) Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates Heparan Sulfate biosynthesis and shapes gastric cancer cell motility and invasion, J Biol Chem (2022). DOI: 10.1016/j.jbc.2022.102546

Matinha-Cardoso J, Coutinho F, Lima S, Eufrásio A, Carvalho AP, Oliva-Teles A, Bessa J, Tamagnini P, Serra CR, Oliveira P (2022) Novel protein carrier system based on cyanobacterial nano-sized extracellular vesicles for application in fish. Microbial Biotechnology, In press. DOI: 10.1111/1751-7915.14057

Mosteo L, Reis J, Rocha L, Lopes M, Duarte D (2022). Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells. Journal of visualized experiments: JoVE, (187), 10.3791/64248. https://doi.org/10.3791/64248

Neves JV, Barroso C, Carvalho P, Nunes M, Gonçalves JFM, Rodrigues PNS (2022). Characterization of erythroferrone in a teleost fish (Dicentrarchus labrax) with two functional hepcidin types: more than an erythroid regulator. Frontiers in Immunology 13:867630. https://doi.org/10.3389/fimmu.2022.867630

Nogueira-Rodrigues J, Leite SC, Pinto-Costa R, Sousa SC, Luz LL, Sintra MA, Oliveira R, Monteiro AC,  Pinheiro GG, Vitorino MS, Silva JA, Simão S, Fernandes VE, Provazník J, Benes V, Cruz CD, Safronov BV,  Magalhães A, Reis CA, Vieira J, Vieira CP, Tiscórnia G, Araújo IM, Sousa MM (2022) Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection. Developmental Cell 57:1–11 DOI: 10.1016/j.devcel.2021.12.008

Osswald, M., Barros-Carvalho, A., Carmo, A.M., Loyer, N., Gracio, P.C., Sunkel, C.E., Homem, C.C.F., Januschke, J., and Morais-de-Sa, E. (2022). aPKC regulates apical constriction to prevent tissue rupture in the Drosophila follicular epithelium. Curr Biol. DOI: 10.1016/j.cub.2022.08.063

Pereira JM, Xu S, Leong JM, Sousa S (2022) The Yin and Yang of Pneumolysin During Pneumococcal Infection. Front. Immunol. 13:878244. DOI: 10.3389/fimmu.2022.878244

Ribeiro R, Macedo JC, Costa M, Ustiyan V, Shindyapina AV, Tyshkovskiy A, Gomes RN, Castro JP, Kalin TV, Vasques-Nóvoa F, Nascimento DS, Gladyshev VN, Kalinichenko VV, Logarinho E (2022) In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan. Nature Aging 2:397-411. DOI: 10.1038/s43587-022-00209-9

Rodrigues PM, Sousa LG, Perrod C, Maceiras AR, Ferreirinha P, Pombinho R, Romera-Cárdenas G, Gomez-Lazaro M, Senkara M, Pistolic J, Cabanes D, Klein L, Saftig P, Alves NL (2022) LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development. Autophagy. DOI: 10.1080/15548627.2022.2074105

Silva-Carvalho R, Leão T, Bourbon AI, Gonçalves C, Pastrana LM, Parpot P, Amorim I, Tomás AM, Gama FM. (2022) Hyaluronic acid-amphotericin B nanocomplexes: a promising anti-leishmanial drug delivery system. Biomater Sci. 2022 Apr 12;10(8):1952-1967. doi: 10.1039/d1bm01769a. PMID: 35253814.

Silva-Carvalho R, Leão T, Gama FM, Tomás AM (2022). Covalent conjugation of amphotericin B to hyaluronic acid: an injectable water-soluble conjugate with reduced toxicity and anti-leishmanial potential. Biomacromolecules, 23(3), 1169-1182. DOI: 10.1021/acs.biomac.1c01451

 

2021

Barroso C, Carvalho P, Gonçalves JFM, Rodrigues PNS, Neves JV (2021). Antimicrobial Peptides: Identification of two Beta-Defensins in a Teleost Fish, the European Sea Bass (Dicentrarchus labrax). Pharmaceuticals 14(6): 566. https://doi.org/10.3390/ph14060566

Barroso C, Carvalho P, Nunes M, Gonçalves JFM, Rodrigues PNS, Neves JV (2021). The Era of Antimicrobial Peptides: use of hepcidins to prevent or treat bacterial infections and iron disorders. Frontiers in Immunology 12:754437. https://doi.org/10.3389/fimmu.2021.754437

Bento CM, Gomes MS, Silva T (2021) Evolution of Antibacterial Drug Screening Methods: Current Prospects for Mycobacteria. Microorganisms 9(12):2562. DOI: 10.3390/microorganisms9122562

Bezerra F, Niemietz C, Schmidt H, Zibert A, Guo S, Monia BP, Gonçalves P, Saraiva MJ, Almeida MR (2021) In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis. International journal of molecular sciences 22(17):9488. DOI: 10.3390/ijms22179488

Cardoso A*, Martins AC*, Maceiras AR, Liu W, Castro I, Castro AG, Bandeira A, Di Santo JP, Cumano A, Li Y, Vieira P, Saraiva M. (2021). Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis. Cell Rep. 37(4):109887. DOI: 10.1016/j.celrep.2021.109887. *Equal contribution as first author

Cardoso D, Lima S, Matinha-Cardoso J, Tamagnini P, Oliveira P (2021). The Role of Outer Membrane Protein(s) Harboring SLH/OprB-Domains in Extracellular Vesicles' Production in Synechocystis sp. PCC 6803. Plants (Basel, Switzerland) 10(12):2757. DOI: 10.3390/plants1012275

Cardoso MS, Santos RF, Almeida S, Sá M, Pérez-Cabezas B, Oliveira L, Tavares J, Carmo AM (2021) Physical interactions with bacteria and protozoan parasites establish the scavenger receptor SSC4D as a broad-spectrum pattern recognition receptor. Front. Immunol. 12:760770. DOI: 10.3389/fimmu.2021.760770

Cotrina EY, Santos LM, Rivas J, Blasi D,  Leite JP, Liz MA, Busquets MA, Planas A, Prohens R, Gimeno A, Jiménez-Barbero J,  Gales L, Llop J, Quintana J, Cardoso I, Gemma A (2021) Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease. European Journal of Medicinal Chemistry 226:113847. DOI: 10.1016/j.ejmech.2021.113847

Duque M, Amorim JP, Bessa J* (2021) Ptf1a function and transcriptional cis-regulation, a cornerstone in vertebrate pancreas development. FEBS J. 289(17):5121-5136. DOI: 10.1111/febs.16075

Eira J, Magalhães J, Macedo N, Pero ME, Misgeld T, Sousa MM, Bartolini F, Liz MA (2021).Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation. Frontiers in Cell and Developmental Biology. DOI:10.3389/fcell.2021.747699

Figueiredo, J., Mercadillo, F., Melo, S., Barroso, A., Goncalves, M., Diaz-Tasende, J., Carneiro, P., Robles, L., Colina, F., Ibarrola, C., et al. (2021). Germline CDH1 G212E Missense Variant: Combining Clinical, In Vitro and In Vivo Strategies to Unravel Disease Burden. Cancers (Basel) 13. DOI: 10.3390/cancers13174359

Gomes RN, Manuel F, Nascimento DS (2021) The bright side of fibroblasts: molecular signature and regenerative cues in major organs. NPJ Regen Med 6(1):43. DOI: 10.1038/s41536-021-00153-z

Laundos TL, Vasques-Nóvoa F, Gomes RN, Sampaio-Pinto V, Cruz P, Cruz H, Santos JM, Barcia RN, Pinto-do-Ó P, Nascimento DS (2021) Consistent Long-Term Therapeutic Efficacy of Human Umbilical Cord Matrix-Derived Mesenchymal Stromal Cells After Myocardial Infarction Despite Individual Differences and Transient Engraftment. Front. Cell Dev. Biol 9:624601. DOI: 10.3389/fcell.2021.624601

Leite J, Lete M, Fowler S, Gimeno A, Rocha J, Sousa S, Webster C, Jiménez-Barbero J, Gales L (2021) Aβ31-35 decreases Neprilysin-mediated Alzheimer’s Amyloid-β peptide degradation. ACS Chemical Neuroscience 12(19):3708-3718. DOI: 10.1021/acschemneuro.1c00432

Magalhães J, Eira J, Liz MA (2021). The role of transthyretin in cell biology: impact on human pathophysiology. Cellular and Molecular Life Sciences. DOI:10.1007/s00018-021-03899-3

Marques C, Reis CA, Vivès RR, Magalhães A (2021) Heparan Sulfate Biosynthesis and Sulfation Profiles as Modulators of Cancer Signalling and Progression. Front Oncol 11:778752. DOI: 10.3389/fonc.2021.778752

Moreira J, Costelha S, Saraiva, M, Saraiva MJ (2021) The expression of chemokines is downregulated in a pre-clinical model of TTR V30M amyloidosis. Frontiers in Immunology 12:650269. DOI: 10.3389/fimmu.2021.650269

Neves JV, Gomes AC, Costa DM, Barroso C, Vaulont S, Cordeiro da Silva A, Tavares J, Rodrigues PNS (2021). A role for hepcidin in the anemia caused by Trypanosoma brucei infection. Haematologica 106(3): 806-818. http://dx.doi.org/10.3324/haematol.2019.227728

Sara Vaz, Fábio J. Ferreira, Joana C. Macedo, Gil Leor, Uri Ben-David, José Bessa & Elsa Logarinho. (2021). FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation. Cell Death & Disease, 12. DOI: 10.1038/s41419-021-03822-5

Santos, M., Pacheco, C.C., Yao, L., Hudson, E.P., Tamagnini, P. (2021) CRISPRi as a tool to repress multiple copies of extracellular polymeric substances (EPS)-related genes in the cyanobacterium Synechocystis sp. PCC 6803. Life 11:1198. doi:10.3390/life11111198

Santos, M., Pereira, S.B., Flores, C., Príncipe, C., Couto, N., Karunakaran, E., Cravo, S.M., Oliveira, P. and Tamagnini, P. (2021) Absence of KpsM (Slr0977) impairs the secretion of extracellular polymeric substances (EPS) and impacts carbon fluxes in Synechocystis sp. PCC 6803. mSphere 6:00003-21. DOI:10.1128/mSphere.00003-21

Silvério, D, Gonçalves, R, Appelberg, R, Saraiva, M (2021) Advances on the Role and Applications of Interleukin-1 in Tuberculosis. mBio 12(6): e03134-21. DOI: 10/1128/mBio.03134-21

 

2020

Amorim JP, Bordeira-Carriço R, Gali-Macedo A, Perrod C and Bessa J* (2020) CRISPR/Cas9 mediated genomic deletions protocol in zebrafish. STAR Protocols 1(3):100208. DOI: 10.1016/j.xpro.2020.100208

Amorim JP, Gali-Macedo A, Marcelino H, Bordeira-Carriço R, Naranjo S, Rivero-Gil S, Teixeira J, Galhardo M, Marques J and Bessa J* (2020) A conserved notochord enhancer controls pancreas development in vertebrates. Cell Reports 32(1):107862. DOI: 10.1016/j.celrep.2020.107862

Barroso C, Carvalho P, Carvalho C, Santarém N, Gonçalves JFM, Rodrigues PNS, Neves JV (2020). The Diverse Piscidin Repertoire of the European Sea Bass (Dicentrarchus labrax): Molecular Characterization and Antimicrobial Activities. International Journal of Molecular Sciences 21(13):4613. http://dx.doi.org/10.3390/ijms21134613

Bezerra F, Saraiva MJ, Almeida MR (2020) Modulation of the Mechanisms Driving Transthyretin Amyloidosis. Frontiers in molecular neuroscience, 13:592644. DOI: 10.3389/fnmol.2020.592644

Carmo AM, Henriques SN (2020) Cell activation and signaling in lymphocytes, in JV Silva, MJ Freitas, M Fardilha (Eds.), Tissue-Specific Cell Signaling, Springer Nature pp133-161. ISBN: 978-3-030-44435-8.

Castro, A.F.; Loureiro, J.R.; Bessa, J.; Silveira, I. Antisense Transcription across Nucleotide Repeat Expansions in Neurodegenerative and Neuromuscular Diseases: Progress and Mysteries. (2020) Genes. 11(12), 1418. https://doi.org/10.3390/genes11121418

Cotrina ElY, Oliveira A,  Leite JP, Llop J,  Gales L, Quintana J, Cardoso I, Gemma A (2020) Repurposing benzbromarone for Familial Amyloid Polyneuropathy: a new transthyretin tetramer stabilizer. International Journal of Molecular Siences 21(9): 7166. DOI: 10.3390/ijms21197166

Cunha-Silva, S., Osswald, M., Goeman, J., Barbosa, J., Santos, L.M., Resende, P., Bange, T., Ferrás, C., Sunkel, C.E., Conde, C. (2020). Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation. Journal of Cell Biology, 219(3). https://doi.org/10.1083/jcb.201906039

Eufrásio A, Perrod C, Ferreira FJ, Duque M, Galhardo M and Bessa J* (2020) In vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes Associated SNPs. Diabetes 69(12):2794-2805. DOI: 10.2337/db19-1049

Fonseca, KL, Maceiras, AR, Matos, R, Simoes-Costa, L, Sousa, J, Cá, B, Barros, L, Fernandes, AI, Mereiter, S, Reis, R, Gomes, J, Tapia, G, Rodríguez-Martínez, P, Martín-Céspedes, M, Vashakidze, S, Gogishvili, S, Nikolaishvili, K, Appelberg, R, Gärtner, F, Rodrigues, PNS, Vilaplana, C, Reis, CA, Magalhães, A, Saraiva, M. (2020) Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils. Mucosal Immunology 13:836-848. DOI:10.1038/s41385-020-0277-7

Gonçalves CF, Lima S, Oliveira P (2020) Product export in cyanobacteria. p. 369-406, in “Cyanobacteria biotechnology”, Wiley Advanced Biotechnology series, edited by Paul Hudson (Editor), WILEY‐VCH GmbH, (ISBN-10: 3527347143, ISBN-13: 978-3527347148). DOI: 10.1002/9783527824908.ch12

Lima S, Matinha-Cardoso J, Tamagnini P, Oliveira P (2020) Extracellular Vesicles: An Overlooked Secretion System in Cyanobacteria. Life, 10(8):129. DOI: 10.3390/life10080129

Mendes R, Figueira F,  Leite J,  Gales L*, Paz F* (2020) Metal-Organic Frameworks: a Future Toolbox for Biomedicine? Chemical Society Reviews 49:9121-9153. DOI: 10.1039/d0cs00883d

Moreira-Teixeira, L, Tabone, O, Graham, CM, Singhania, A, Stavropoulos, E, Redford, PS, Chakravarty, P, Priestnall, SL, Suarez-Bonnet, A, Herbert, E, Mayer-Barber, KD, Sher, A, Fonseca, KL, Sousa J, Cá B, Verma, R, Haldar, P, Saraiva, M, O'Garra, A. (2020) Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis. Nature Immunology 21:464-476. DOI:10.1038/s41590-020-0610-z

Niemietz C, Bezerra F, Almeida MR, Guo S, Monia BP, Saraiva MJ, Schütz P, Schmidt HH, Zibert A (2020) SERPINA1 modulates expression of amyloidogenic transthyretin. Experimental cell research 395(2):112217. DOI: 10.1016/j.yexcr.2020.112217

Oliveira da Silva, MI, Lopes, CS, Liz, MA (2020) Transthyretin interacts with actin regulators in a Drosophila model of familial amyloid polyneuropathy. Scientific Reports 10:13596. DOI: 10.1038/s41598-020-70377-4

Oliveira da Silva, MI, Liz, MA (2020) Linking alpha-synuclein to the actin cytoskeleton: consequences to neuronal function. Frontiers in Cell and Developmental Biology. 8:787. DOI: 10.3389/fcell.2020.00787

Pires, SDS.*; Oliveira, R*; Moradas-Ferreira, P, Mendes, MV (2020) The onset of tacrolimus biosynthesis in Streptomyces tsukubaensis is dependent on the intracellular redox status. Antibiotics 9:703. DOI:10.3390/antibiotics9100703 *These authors contributed equally to this work.

Sousa, J*, Cá, B*, Maceiras, AR, Simões-Costa, L, Fonseca, KL, Fernandes, AI, Ramos, A, Carvalho, T, Barros, L, Magalhães, C, Chiner-Oms, Á, Machado, H, Veiga, MI, Singh, A, Pereira, R, Amorim, A, Vieira, J, Vieira, CP, Bhatt, A, Rodrigues, F, Rodrigues, PNS, Gagneux, S, Castro, AG, Guimarães, JT, Bastos, HN, Osório, NS, Comas, I, Saraiva, M. (2020) Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production. Nature Communications 11:1949. doi:10.1038/s41467-020-15832-6 *These authors contributed equally to this work.

Ventura, G., Moreira, S., Barros-Carvalho, A., Osswald, M., and Morais-de-Sa, E. (2020). Lgl cortical dynamics are independent of binding to the Scrib-Dlg complex but require Dlg-dependent restriction of aPKC. Development 147. DOI: 10.1242/dev.186593

 

2019

Barroso-Vilares, M., and Logarinho, E. (2019), Chromosomal instability and pro-inflammatory response in aging. Mechanisms of ageing and development, 182: 111118. https://doi.org/10.1016/j.mad.2019.111118 (Review)

Bezerra F, Simões C, Beirão JM, Saraiva MJ, Brito R, Almeida MR (2019) Targeting transthyretin amyloidosis in the eye with next-generation stabilizers: AT40 displays potent TTR stabilization in the human vitreous. Amyloid: the international journal of experimental and clinical investigation: the official journal of the International Society of Amyloidosis 26(sup1):73-74.  DOI: 10.1080/13506129.2019.1583193

Brito, C.; Mesquita, F.S.; Bleck, C.K.E.; Sellers, J.R.; Cabanes, D.; Sousa, S. Perfringolysin O-Induced Plasma Membrane Pores Trigger Actomyosin Remodeling and Endoplasmic Reticulum Redistribution. Toxins 2019, 11(7), 419. https://doi.org/10.3390/toxins11070419

Brito, C.; Cabanes, D.; Mesquita, F.S.; Sousa, S. Mechanisms protecting host cells against bacterial pore-forming toxins. Cell. Mol. Life Sci. 2019, 76, 1319–1339. Review. https://doi.org/10.1007/s00018-018-2992-8

Cá, Baltazar; Fonseca, Kaori L.; Sousa, Jeremy; Maceiras, Ana Raquel; Machado, Dia-na; Sanca, Lilica; Rabna, Paulo; et al. 2019. "Experimental Evidence for Limited in vivo Virulence of Mycobacterium africanum". Frontiers in Microbiology 10. http://dx.doi.org/10.3389/fmicb.2019.02102

Cereija, T.B., Alarico, S., Lourenço, E.C., Manso, J.A., Ventura, M. R., Empadinhas, N., Macedo-Ribeiro, S., Pereira, P.J.B. (2019), The structural characterization of a glucosyl-glycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation. IUCrJ, 6(Pt 4):572-585. https://doi.org/10.1107/S2052252519005372

Flores, C., Lima, R. T., Adessi, A., Sousa, A., Pereira, S. B., Granja, P. L., De Philippis, R., Soares, P., & Tamagnini, P. (2019), Characterization and antitumor activity of the extracellular carbohydrate polymer from the cyanobacterium Synechocystis ΔsigF mutant. International Journal of Biological Macromolecules, 136: 1219-1227. https://doi.org/10.1016/j.ijbiomac.2019.06.152

Flores, C., & Tamagnini, P. (2019), Looking Outwards: Isolation of Cyanobacterial Re-leased Carbohydrate Polymers and Proteins. JoVE - J. Vis. Exp., 147: e59590. https://doi.org/10.3791/59590

Flores, C., Santos, M., Pereira, S. B., Mota, R., Rossi, F., De Philippis, R., Couto, N., Karunakaran, E., Wright, P. C., Oliveira, P., & Tamagnini, P. (2019), The alternative sigma fac-tor SigF is a key player in the control of secretion mechanisms in Synechocystis sp. PCC 6803. Environmental Microbiology, 21: 343–359. https://doi.org/10.1111/1462-2920.14465

Freitas, RF., Basto, A., Almeida, SCP., Santos, RF., Gonçalves, CM., Corria-Osorio, J., Carvalho, T., Carmo, AM., Oliveira, VG., Leon, K., Graça, L. (2019). Modulation of CD4 T cell function via CD6-targeting. EBioMedicine. 2019 Aug 14. pii: S2352-3964(19)30524-9. DOI: https://doi.org/10.1016/j.ebiom.2019.08.008

Ghazaryan N., Movsisyan N., Macedo J.C., Vaz S., Ayvazyan N., Pardo L., Logarinho E. (2019), The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model. Invest New Drugs. https://doi.org/10.1007/s10637-019-00734-2 [Epub ahead of print]

Gonçalves, C.F., Lima, S., Tamagnini, P., and Oliveira, P. (2019). Cyanobacterial secretion systems: understanding fundamental mechanisms towards technological applications. p. 359-381, in "Cyanobacteria: from basic science to applications" (ISBN: 9780128146675), eds. A.K. Mishra, D.N. Tiwari, A.N. Rai. Academic Press, Elsevier, Lon-don, UK.

Leite, J. P.; Rodrigues, D.; Ferreira, S.; Figueira, F.; Almeida Paz, F. A.; Gales, L., Mesoporous Metal-Organic Frameworks as Effective Nucleating Agents in Protein Crystallography. Crystal Growth & Design 2019, 19 (3), 1610-1615. https://doi.org/10.1021/acs.cgd.8b01444

Leite, J. P.; Gales, L., Alzheimer's Aβ1-40 peptide degradation by thermolysin: evidence of inhibition by a C-terminal Aβ product. FEBS Letters 2019, 593 (1), 128-137. https://doi.org/10.1002/1873-3468.13285

Leite, J. P., Gales, L. (2019), Fluorescence properties of the amyloid indicator dye thioflavin T in constrained environments. Dyes and Pigments, 160(64-70). https://doi.org/10.1016/j.dyepig.2018.07.049

Loureiro, J. R., Oliveira, C. L., Mota, C., Castro, A. F., Costa, C., Loureiro, J. L., Coutinho, P., Martins, S., Sequeiros, J., Silveira, I. (2019). Mutational Mechanism for DAB1 (ATTTC)_n insertion in SCA37: ATTTT Repeat Lengthening and Nucleotide substitution. Human Mutation, 40:404-412. https://doi.org/10.1002/humu.23704

Malheiro AR, Correia B, Ferreira da Silva T, Bessa-Neto D, Van Veldhoven PP, Brites P. (2019) “Leukodystrophy caused by plasmalogen deficiency rescued by glyceryl 1-myristyl ether treatment” Brain Pathol, Jan 22. https://doi.org/10.1111/bpa.12710

Moreira, S., Osswald, M., Ventura, G., Gonçalves, M., Sunkel, C.E., and Morais-de-Sá, E. (2019). PP1-Mediated Dephosphorylation of Lgl Controls Apical-basal Polarity. Cell Rep. 26, 293-301.e7. https://doi.org/10.1016/j.celrep.2018.12.060

Moura, M., Conde, C. (2019), Phosphatases in Mitosis: Roles and regulation. Biomolecules 9 (2), 55 (Review)

Oliveira M.S., Freitas J., Pinto P., Jesus A., Tavares J., Pinho M., Lopes C., Conde C., Sunkel C. and Moreira A. (2019), Cell Cycle Kinase Polo Is Controlled by a Widespread 3’ Untranslated Region Regulatory Sequence in Drosophila melanogaster. Molecular and Cell Biology. https://doi.org/10.1128/MCB.00581-18

Pereira SB, Sousa A, Santos M, Araújo M, Serôdio F, Granja PL, Tamagnini, P. (2019) Strategies to obtain designer polymers based on cyanobacterial extracelular polymeric substances (EPS). International Journal of Molecular Sciences 20:5693. DOI:10.3390/ijms20225693

Pinho, M., Macedo, J.C., Logarinho, E., Pereira, P.S. (2019). NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging. Mol Cell Biol. 2019 May 28;39(12). https://doi.org/10.1128/MCB.00099-19

Rocha, R., Teixeira-Duarte, C. M., Jorge, J. M. P., & Morais-Cabral, J. H. (2019). Characterization of the molecular properties of KtrC, a second RCK domain that regulates a Ktr channel in Bacillus subtilis. J Struct Biol, 205(3), 34-43. https://doi.org/10.1016/j.jsb.2019.02.002

Santos, RF., Oliveira, L., Brown, MH., Carmo, AM. (2019). Domain‐specific CD6 monoclonal antibodies identify CD6 isoforms generated by alternative splicing. Immunology. 2019 Aug;157(4):296-303. https://doi.org/10.1111/imm.13087

Shukla S., Milewski D., Pradhan A., Rama N., Rice K., Le T., Flick M.J., Vaz S., Zhao X., Setchell K.D., Logarinho E., Kalinichenko V.V., Kalin T.V. (2019), The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear β-Catenin. Mol Cancer Ther;18:1217–29. https://doi.org/10.1158/1535-7163.MCT-18-0709

Simões C, Almeida ZL, Cardoso AL, Bezerra F, Almeida MR, Beirão J, Pinho E Melo T, Saraiva MJ, Brito R (2019) Lead optimization of resilient next-generation transthyretin stabilizers for multiple target-product profiles: approaching the CNS. Amyloid: the international journal of experimental and clinical investigation: the official journal of the International Society of Amyloidosis, 26(sup1):77–78. DOI: 10.1080/13506129.2019.1583195

Teixeira-Duarte CM, Fonseca F, Morais-Cabral JH. "Activation of a Nucleotide-Dependent RCK Domain Requires Binding of a Cation Cofactor to a Conserved Site.” eLife (2019), 8:e50661 DOI: 10.7554/eLife.50661

 

2018

Costa, A. R., Pinto-Costa, R., Sousa, S. C., Sousa, M. M. (2018), The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swell-ing. Front. Mol. Neurosci., 11: 319. https://doi.org/10.3389/fnmol.2018.00319 (Review)

De Munter S, Bamps D, Malheiro AR, Kumar Baboota R, Brites P, Baes M. (2018) “Autonomous Purkinje cell axonal dystrophy causes ataxia in peroxisomal multifunctional protein-2 deficiency” Brain Pathol, Sep;28(5):631-643. https://doi.org/10.1111/bpa.12586

Gonçalves, CM., Henriques, SH., Santos, RF., Carmo, AM. (2018). CD6, a Rheostat-Type Signalosome That Tunes T Cell Activation. Front. Immunol. 2018 Dec; 18;9:2994. https://doi.org/10.3389/fimmu.2018.02994

Leite, J. P. and Gales, L. (2018), Alzheimer's Aβ1‐40 peptide degradation by thermolysin: evidence of inhibition by a C‐terminal Aβ product. FEBS Lett. https://doi.org/10.1002/1873-3468.13285

Loureiro, J. R., Oliveira, C. L., Sequeiros, J., Silveira, I. (2018), A repeat-primed PCR as-say for pentanucleotide repeat alleles in spinocerebellar ataxia type 37. J. Hum. Genet., 63:981-987. https://doi.org/10.1038/s10038-018-0474-3

Macedo, J. C., Vaz, S., Bakker, B., Ribeiro, R., Bakker, P. L., Escandell, J. M., Ferreira, M. G., Medema, R., Foijer, F., Logarinho, E. (2018), FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence. Nat. Commun., 19;9(1):2834. https://doi.org/10.1093/cercor/bhx023

Nascimento, A. I., Mar, F. M., Sousa, M. M. (2018), The intriguing nature of dorsal root ganglion neurons: Linking structure with polarity and function. Prog. Neurobiol., 168:86-103. https://doi.org/10.1016/j.pneurobio.2018.05.002

Novais-Cruz, M., Abad, M. A., van Ijcken, W. F. J., Galjart, N., Jeyaprakash, A. A., Maiato, H., Ferrás, C. (2018), Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription. eLife, 7: e36898. https://doi.org/10.7554/eLife.36898

Oliveira, L, Santos, RF, Carmo, AM (2018) CD6, in S. Choi (Ed.), Encyclopedia of Signalling Molecules, 2nd Edn., Springer, pp937-943.

Pereira, S. B.*, Santos, M.*, Leite, J. P., Flores, C., Eisfeld, C., Buttel, Z., Mota, R., Rossi, F., De Philippis, R., Cabral, J. M. And Tamagnini, P. (2018), The role of the tyrosine ki-nase Wzc (Sll0923) and the phosphatase Wzb (Slr0328) in the production of extracellular polymeric substances (EPS) by Synechocystis PCC 6803. Microbiology-Open. https://doi.org/10.1002/mbo3.753 *These authors contributed equally to this work.

Sousa J, Saraiva M. Paradigm changing evidence that alter tuberculosis perception and detection: Focus on latency. Infect Genet Evol. (2019),72:78-85. DOI: 10.1016/j.meegid.2018.12.019 Epub 2018 Dec 18.PMID: 30576838

 

2017

Cereija, T. B., Alarico, S., Empadinhas, N., Pereira, P. J. B. (2017), Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase. Ac-ta Crystallogr. F Struct. Biol. Commun., 73(Pt 9):536-540. https://doi.org/10.1107/S2053230X17012419

Fixman, B. B., Babcock, I. W., Minamide, L. S., Shaw, A. E., da Silva, M. I. O., Runyan, A. M., ... & Bamburg, J. R. (2017). Modified Roller Tube Method for Precisely Localized and Repetitive Intermittent Imaging During Long-term Culture of Brain Slices in an Enclosed System. JoVE (Journal of Visualized Experiments), (130), e56436. https://doi.org/10.3791/56436

Fonseca, K.L., Rodrigues, P. N. S., Olsson, I. A. S., Saraiva, M. (2017), Experimental study of tuberculosis: From animal models to complex cell systems and organoids. PloS Pathog. 13(8):e1006421. https://doi.org/10.1371/journal.ppat.1006421

Franquinho. F., Nogueira-Rodrigues, J., Duarte. J.M., Esteves, S.S., Carter-Su, C., Mona-co A.P., Molnár, Z., Velayos-Baeza, A., Brites, P., Sousa, M.M. (2017) The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling. Cereb Cortex. 1;27(3):1732-1747. https://doi.org/10.1093/cercor/bhx023

Liu, X., Freitas, J., Zheng, D., Oliveira, M. S., Hoque, M., Martins, T., Henriques, T., Tian, B., and Moreira, A. (2017), Transcription elongation rate has a tissue-specific impact on alternative cleavage and 3 polyadenylation in Drosophila melanogaster. RNA, 23(12), 1807-1816. https://doi.org/10.1261/rna.062661.117

Macedo, J. C., Vaz, S., Logarinho, E. (2017), Mitotic dysfunction associated with aging hallmarks. Adv. Exp. Med. Biol., 1002:153-188. https://doi.org/10.1007/978-3-319-57127-0_7 (Book Chapter)

Maiato, H., Gomes, A. M., Sousa, F., Barisic, M. (2017), Mechanisms of chromosome congression during mitosis. Biology (Basel), 6(1). pii: E13. https://doi.org/10.3390/biology6010013 (Review)

Meireles, C., Ribeiro, A. R., Pinto, R. D., Leitão, C., Rodrigues, P. M. and Alves, N. L. (2017), Thymic crosstalk restrains the pool of cortical thymic epithelial cells with progenitor properties. Eur. J. Immunol., 47: 958-969. https://doi.org/10.1002/eji.201746922

Mesquita, F.S.; Brito, C.; Cabanes, D.; Sousa, S. Control of cytoskeletal dynamics during cellular responses to pore forming toxins. Commun. Integr. Biol. 2017, 10, e1349582. https://doi.org/10.1080/19420889.2017.1349582

Mesquita, F.S.; Brito, C.; Mazon Moya, M.J.; Pinheiro, J.C.; Mostowy, S.; Cabanes, D.; Sousa, S. Endoplasmic reticulum chaperone Gp96 controls actomyosin dynamics and protects against pore-forming toxins. EMBO Rep. 2017, 18, 303–318. https://doi.org/10.15252/embr.201642833

Seixas, A. I., Loureiro, J. R., Costa, C., Ordóñez-Ugalde, A., Marcelino, H., Oliveira, C. L., Loureiro, J. L., Dhingra, A., Brandão, E., Cruz, V. T., Timóteo, A., Quintáns, B., Rouleau, G. A., Rizzu, P., Carracedo, A., Bessa, J., Heutink, P., Sequeiros, J., Sobrido, M. J., Coutinho, P., Silveira, I. (2017), A Pentanucleotide ATTTC Repeat Insertion in the Non-coding Re-gion of DAB1, Mapping to SCA37, Causes Spinocerebellar Ataxia. Am. J. Hum. Genet., 101(1):87-103. https://doi.org/10.1016/j.ajhg.2017.06.007

Shinde AB, Baboota RK, Denis S, Loizides-Mangold U, Peeters A, Espeel M, Malheiro AR, Riezman H, Vinckier S, Vaz FM, Brites P, Ferdinandusse S, Van Veldhoven PP, Baes M. (2017) “Mitochondrial disruption in peroxisome deficient cells is hepatocyte selective but is not mediated by common hepatic peroxisomal metabolites.” Mitochondrion. 2017 Sep 1. pii: S1567-7249(17)30218-0. https://doi.org/10.1016/j.mito.2017.08.013

Silva, C. S., Eira, J., Ribeiro, C. A., Oliveira, Â., Sousa, M. M., Cardoso, I., Liz, M. A. (2017), Transthyretin neuroprotection in Alzheimer's disease is dependent on proteolysis. Neurobiol. Aging, 59:10-14. https://doi.org/10.1016/j.neurobiolaging.2017.07.002

Teixeira, C., Costelha, S., Martins, H. S., Teixeira, A., Saraiva, M. J. (2017), Doxycycline-tauroursodeoxycholic acid treatment: effects in the heart of a transthyretin V30M transgenic mouse model. Amyloid, 24(sup1):80. https://doi.org/10.1080/13506129.2016.1277695

 

2016

Bessa-Pereira, C, Bocková, M, Santos, RF, Santos, AM, Martins de Araújo, M, Oliveira, L, Homola, J, Carmo, AM (2016) The scavenger receptor SSc5D physically interacts with bacteria through the SRCR-containing N-terminal domain. Frontiers in Immunology 7:416. DOI:10.3389/fimmu.2016.00416

De Munter S, Verheijden S, Vanderstuyft E, Malheiro AR, Brites P, Gall D, Schiffmann SN, Baes M. (2016) “Early-onset Purkinje cell dysfunction underlies cerebellar ataxia in peroxisomal multifunctional protein-2 deficiency”, Neurobiol Dis, Oct;94:157-68. https://doi.org/10.1016/j.nbd.2016.06.012

Leite, S. C., Sampaio, P., Sousa, V. F., Nogueira-Rodrigues, J., Pinto-Costa, R., Peters, L.L., Brites, P., Sousa, M. M. (2016), The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter. Cell Rep., 15(3):490-498. https://doi.org/10.1016/j.celrep.2016.03.047

Loureiro, J. R., Oliveira, C. L., Silveira, I. (2016), Unstable repeat expansions in neurodegenerative diseases: nucleocytoplasmic transport emerges on the scene. Neurobiol. Aging, 39:174-183. https://doi.org/10.1016/j.neurobiolaging.2015.12.007 (Review)

Moreira, S., and Morais-de-Sá, E. (2016). Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons. BioArchitecture 6, 29–38. https://doi.org/10.1080/19490992.2016.1149290

Moreira-Teixeira L, Sousa J, McNab FW, Torrado E, Cardoso F, Machado H, Castro F, Cardoso V, Gaifem J, Wu X, Appelberg R, Castro AG, O'Garra A, Saraiva M. Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling. J Immunol. (2016),15;197(12):4714-4726. DOI: 10.4049/jimmunol.1600584 PMID:27849167

Santos, RF, Oliveira, L, Carmo, AM (2016) Tuning T cell activation: the function of CD6 at the immunological synapse and in T cell responses. Current Drug Targets 17:630-639. DOI:10.2174/1389450116666150531152439

Szollosi, A., Vieira-Pires, R. S., Teixeira-Duarte, C. M., Rocha, R., & Morais-Cabral, J. H. (2016). Dissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the KtrAB K+ Transporter. PLoS Biol, 14(1), e1002356. https://doi.org/10.1371/journal.pbio.1002356

Teixeira, C. A., Almeida, M. R., Saraiva, M.J. (2016), Impairment of autophagy by TTR V30M aggregates: in vivo reversal by TUDCA and curcumin. Clin. Sci. (Lond), 130(18):1665-75. https://doi.org/10.1042/CS20160075

 

2015

Malheiro AR, Ferreira da Silva T, and Brites P. (2015) “Plasmalogens and fatty alcohols in Rhizomelic Chondrodysplasia Punctata and Sjogren-Larsson syndrome”, J Inherit Metab Dis, Jan;38(1):111-21. https://doi.org/10.1007/s10545-014-9795-3