2020

Cá, Baltazar; Jeremy Sousa; Ana Raquel Maceiras; Ana Costa; Kaori L. Fonseca; Ana Fernandes; Angélica Ramos; et al. 2020."Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1ß production". Nature Communications. In press.

Cunha-Silva, S., Osswald, M., Goeman, J., Barbosa, J., Santos, L.M., Resende, P., Bange, T., Ferrás, C., Sunkel, C.E., Conde, C. (2020). Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation. Journal of Cell Biology, 219(3). https://doi.org/10.1083/jcb.201906039

 

2019

Cá, Baltazar; Fonseca, Kaori L.; Sousa, Jeremy; Maceiras, Ana Raquel; Machado, Diana; Sanca, Lilica; Rabna, Paulo; et al. 2019. "Experimental Evidence for Limited in vivo Virulence of Mycobacterium africanum". Frontiers in Microbiology 10. http://dx.doi.org/10.3389/fmicb.2019.02102.

Teixeira-Duarte CM, Fonseca F, Morais-Cabral JH. "Activation of a Nucleotide-Dependent RCK Domain Requires Binding of a Cation Cofactor to a Conserved Site.” eLife (2019), 8:e50661 doi: 10.7554/eLife.50661

Moura, M., Conde, C. (2019), Phosphatases in Mitosis: Roles and regulation. Biomolecules 9 (2), 55 (Review)

Rocha, R., Teixeira-Duarte, C. M., Jorge, J. M. P., & Morais-Cabral, J. H. (2019). Characterization of the molecular properties of KtrC, a second RCK domain that regulates a Ktr channel in Bacillus subtilis. J Struct Biol, 205(3), 34-43. https://doi.org/10.1016/j.jsb.2019.02.002

Moreira, S., Osswald, M., Ventura, G., Gonçalves, M., Sunkel, C.E., and Morais-de-Sá, E. (2019). PP1-Mediated Dephosphorylation of Lgl Controls Apical-basal Polarity. Cell Rep. 26, 293-301.e7. https://doi.org/10.1016/j.celrep.2018.12.060

Oliveira M.S., Freitas J., Pinto P., Jesus A., Tavares J., Pinho M., Lopes C., Conde C., Sunkel C. and Moreira A. (2019), Cell Cycle Kinase Polo Is Controlled by a Widespread 3’ Untranslated Region Regulatory Sequence in Drosophila melanogaster. Molecular and Cell Biology. https://doi.org/10.1128/MCB.00581-18

Cereija, T.B., Alarico, S., Lourenço, E.C., Manso, J.A., Ventura, M. R., Empadinhas, N., Macedo-Ribeiro, S., Pereira, P.J.B. (2019), The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation. IUCrJ, 6(Pt 4):572-585. https://doi.org/10.1107/S2052252519005372

Brito, C.; Mesquita, F.S.; Bleck, C.K.E.; Sellers, J.R.; Cabanes, D.; Sousa, S. Perfringolysin O-Induced Plasma Membrane Pores Trigger Actomyosin Remodeling and Endoplasmic Reticulum Redistribution. Toxins 2019, 11(7), 419. https://doi.org/10.3390/toxins11070419

Brito, C.; Cabanes, D.; Mesquita, F.S.; Sousa, S. Mechanisms protecting host cells against bacterial pore-forming toxins. Cell. Mol. Life Sci. 2019, 76, 1319–1339. Review. https://doi.org/10.1007/s00018-018-2992-8

Freitas, RF., Basto, A., Almeida, SCP., Santos, RF., Gonçalves, CM., Corria-Osorio, J., Carvalho, T., Carmo, AM., Oliveira, VG., Leon, K., Graça, L. (2019). Modulation of CD4 T cell function via CD6-targeting. EBioMedicine. 2019 Aug 14. pii: S2352-3964(19)30524-9. doi: https://doi.org/10.1016/j.ebiom.2019.08.008

Santos, RF., Oliveira, L., Brown, MH., Carmo, AM. (2019). Domain‐specific CD6 monoclonal antibodies identify CD6 isoforms generated by alternative‐splicing. Immunology. 2019 Aug;157(4):296-303. https://doi.org/10.1111/imm.13087

Pinho, M., Macedo, J.C., Logarinho, E., Pereira, P.S. (2019). NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging. Mol Cell Biol. 2019 May 28;39(12). https://doi.org/10.1128/MCB.00099-19

Flores, C., Lima, R. T., Adessi, A., Sousa, A., Pereira, S. B., Granja, P. L., De Philippis, R., Soares, P., & Tamagnini, P. (2019), Characterization and antitumor activity of the extracellular carbohydrate polymer from the cyanobacterium Synechocystis ΔsigF mutant. International Journal of Biological Macromolecules, 136: 1219-1227. https://doi.org/10.1016/j.ijbiomac.2019.06.152

Flores, C., & Tamagnini, P. (2019), Looking Outwards: Isolation of Cyanobacterial Released Carbohydrate Polymers and Proteins. JoVE - J. Vis. Exp., 147: e59590. https://doi.org/10.3791/59590

Flores, C., Santos, M., Pereira, S. B., Mota, R., Rossi, F., De Philippis, R., Couto, N., Karunakaran, E., Wright, P. C., Oliveira, P., & Tamagnini, P. (2019), The alternative sigma factor SigF is a key player in the control of secretion mechanisms in Synechocystis sp. PCC 6803. Environmental Microbiology, 21: 343–359. https://doi.org/10.1111/1462-2920.14465

Loureiro, J. R., Oliveira, C. L., Mota, C., Castro, A. F., Costa, C., Loureiro, J. L., Coutinho, P., Martins, S., Sequeiros, J., Silveira, I. (2019). Mutational Mechanism for DAB1 (ATTTC)n insertion in SCA37: ATTTT Repeat Lengthening and Nucleotide substitution. Human Mutation, 40:404-412. https://doi.org/10.1002/humu.23704

Malheiro AR, Correia B, Ferreira da Silva T, Bessa-Neto D, Van Veldhoven PP, Brites P. (2019) “Leukodystrophy caused by plasmalogen deficiency rescued by glyceryl 1-myristyl ether treatment” Brain Pathol, Jan 22. https://doi.org/10.1111/bpa.12710

Shukla S., Milewski D., Pradhan A., Rama N., Rice K., Le T., Flick M.J., Vaz S., Zhao X., Setchell K.D., Logarinho E., Kalinichenko V.V., Kalin T.V. (2019), The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear β-Catenin. Mol Cancer Ther;18:1217–29. https://doi.org/10.1158/1535-7163.MCT-18-0709.

Ghazaryan N., Movsisyan N., Macedo J.C., Vaz S., Ayvazyan N., Pardo L., Logarinho E. (2019), The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model. Invest New Drugs. https://doi.org/10.1007/s10637-019-00734-2. [Epub ahead of print]

Barroso-Vilares, M., and Logarinho, E. (2019), Chromosomal instability and pro-inflammatory response in aging. Mechanisms of ageing and development, 182: 111118. https://doi.org/10.1016/j.mad.2019.111118. (Review)

Gonçalves, C.F., Lima, S., Tamagnini, P., and Oliveira, P. (2019). Cyanobacterial secretion systems: understanding fundamental mechanisms towards technological applications. p. 359-381, in "Cyanobacteria: from basic science to applications" (ISBN: 9780128146675), eds. A.K. Mishra, D.N. Tiwari, A.N. Rai. Academic Press, Elsevier, London, UK.

Leite, J. P.; Rodrigues, D.; Ferreira, S.; Figueira, F.; Almeida Paz, F. A.; Gales, L., Mesoporous Metal–Organic Frameworks as Effective Nucleating Agents in Protein Crystallography. Crystal Growth & Design 2019, 19 (3), 1610-1615. https://doi.org/10.1021/acs.cgd.8b01444

Leite, J. P.; Gales, L., Alzheimer's Aβ1-40 peptide degradation by thermolysin: evidence of inhibition by a C-terminal Aβ product. FEBS Letters 2019, 593 (1), 128-137. https://doi.org/10.1002/1873-3468.13285

Leite, J. P., Gales, L. (2019), Fluorescence properties of the amyloid indicator dye thioflavin T in constrained environments. Dyes and Pigments, 160(64-70). https://doi.org/10.1016/j.dyepig.2018.07.049

 

2018

Sousa J, Saraiva M. Paradigm changing evidence that alter tuberculosis perception and detection: Focus on latency. Infect Genet Evol. (2019),72:78-85. doi: 10.1016/j.meegid.2018.12.019. Epub 2018 Dec 18.PMID: 30576838

Gonçalves, CM., Henriques, SH., Santos, RF., Carmo, AM. (2018). CD6, a Rheostat-Type Signalosome That Tunes T Cell Activation. Front. Immunol. 2018 Dec; 18;9:2994. https://doi.org/10.3389/fimmu.2018.02994

De Munter S, Bamps D, Malheiro AR, Kumar Baboota R, Brites P, Baes M. (2018) “Autonomous Purkinje cell axonal dystrophy causes ataxia in peroxisomal multifunctional protein-2 deficiency” Brain Pathol, Sep;28(5):631-643. https://doi.org/10.1111/bpa.12586

Leite, J. P. and Gales, L. (2018), Alzheimer's Aβ1‐40 peptide degradation by thermolysin: evidence of inhibition by a C‐terminal Aβ product. FEBS Lett. https://doi.org/10.1002/1873-3468.13285

Pereira, S. B.*, Santos, M.*, Leite, J. P., Flores, C., Eisfeld, C., Buttel, Z., Mota,R., Rossi, F., De Philippis, R., Cabral, J. M. And Tamagnini, P. (2018), The role of the tyrosine kinase Wzc (Sll0923) and the phosphatase Wzb (Slr0328) in the production of extracellular polymeric substances (EPS) by Synechocystis PCC 6803. MicrobiologyOpen. https://doi.org/10.1002/mbo3.753 *These authors contributed equally to this work.

Nascimento, A. I., Mar, F. M., Sousa, M. M. (2018), The intriguing nature of dorsal root ganglion neurons: Linking structure with polarity and function. Prog. Neurobiol., 168:86-103. https://doi.org/10.1016/j.pneurobio.2018.05.002

Costa, A. R., Pinto-Costa, R., Sousa, S. C., Sousa, M. M. (2018), The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swelling. Front. Mol. Neurosci., 11: 319. https://doi.org/10.3389/fnmol.2018.00319. (Review)

Loureiro, J. R., Oliveira, C. L., Sequeiros, J., Silveira, I. (2018), A repeat-primed PCR assay for pentanucleotide repeat alleles in spinocerebellar ataxia type 37. J. Hum. Genet., 63:981-987. https://doi.org/10.1038/s10038-018-0474-3

Novais-Cruz, M., Abad, M. A., van Ijcken, W. F. J., Galjart, N., Jeyaprakash, A. A., Maiato, H., Ferrás, C. (2018), Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription. eLife, 7: e36898. https://doi.org/10.7554/eLife.36898

Macedo, J. C., Vaz, S., Bakker, B., Ribeiro, R., Bakker, P. L., Escandell, J. M., Ferreira, M. G., Medema, R., Foijer, F., Logarinho, E. (2018), FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence. Nat. Commun., 19;9(1):2834. https://doi.org/10.1093/cercor/bhx023

 

2017

Franquinho. F., Nogueira-Rodrigues, J., Duarte. J.M., Esteves, S.S., Carter-Su, C., Monaco A.P., Molnár, Z., Velayos-Baeza, A., Brites, P., Sousa, M.M. (2017) The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling. Cereb Cortex. 1;27(3):1732-1747. https://doi.org/10.1093/cercor/bhx023

Mesquita, F.S.; Brito, C.; Cabanes, D.; Sousa, S. Control of cytoskeletal dynamics during cellular responses to pore forming toxins. Commun. Integr. Biol. 2017, 10, e1349582. https://doi.org/10.1080/19420889.2017.1349582

Mesquita, F.S.; Brito, C.; Mazon Moya, M.J.; Pinheiro, J.C.; Mostowy, S.; Cabanes, D.; Sousa, S. Endoplasmic reticulum chaperone Gp96 controls actomyosin dynamics and protects against pore-forming toxins. EMBO Rep. 2017, 18, 303–318. https://doi.org/10.15252/embr.201642833

Shinde AB, Baboota RK, Denis S, Loizides-Mangold U, Peeters A, Espeel M, Malheiro AR, Riezman H, Vinckier S, Vaz FM, Brites P, Ferdinandusse S, Van Veldhoven PP, Baes M. (2017) “Mitochondrial disruption in peroxisome deficient cells is hepatocyte selective but is not mediated by common hepatic peroxisomal metabolites.” Mitochondrion. 2017 Sep 1. pii: S1567-7249(17)30218-0. https://doi.org/10.1016/j.mito.2017.08.013

Fixman, B. B., Babcock, I. W., Minamide, L. S., Shaw, A. E., da Silva, M. I. O., Runyan, A. M., ... & Bamburg, J. R. (2017). Modified Roller Tube Method for Precisely Localized and Repetitive Intermittent Imaging During Long-term Culture of Brain Slices in an Enclosed System. JoVE (Journal of Visualized Experiments), (130), e56436. https://doi.org/10.3791/56436

Maiato, H., Gomes, A. M., Sousa, F., Barisic, M. (2017), Mechanisms of chromosome congression during mitosis. Biology (Basel), 6(1).pii: E13. https://doi.org/10.3390/biology6010013 (Review)

Teixeira, C., Costelha, S., Martins, H. S., Teixeira, A., Saraiva, M. J. (2017), Doxycycline-tauroursodeoxycholic acid treatment: effects in the heart of a transthyretin V30M transgenic mouse model. Amyloid, 24(sup1):80. https://doi.org/10.1080/13506129.2016.1277695

Meireles, C., Ribeiro, A. R., Pinto, R. D., Leitão, C., Rodrigues, P. M. and Alves, N. L. (2017), Thymic crosstalk restrains the pool of cortical thymic epithelial cells with progenitor properties. Eur. J. Immunol., 47: 958-969. https://doi.org/10.1002/eji.201746922

Silva, C. S., Eira, J., Ribeiro, C. A., Oliveira, Â., Sousa, M. M., Cardoso, I., Liz, M. A. (2017), Transthyretin neuroprotection in Alzheimer's disease is dependent on proteolysis. Neurobiol. Aging, 59:10-14. https://doi.org/10.1016/j.neurobiolaging.2017.07.002

Seixas, A. I., Loureiro, J. R., Costa, C., Ordóñez-Ugalde, A., Marcelino, H., Oliveira, C. L., Loureiro, J. L., Dhingra, A., Brandão, E., Cruz, V. T., Timóteo, A., Quintáns, B., Rouleau, G. A., Rizzu, P., Carracedo, A., Bessa, J., Heutink, P., Sequeiros, J., Sobrido, M. J., Coutinho, P., Silveira, I. (2017), A Pentanucleotide ATTTC Repeat Insertion in the Non-coding Region of DAB1, Mapping to SCA37, Causes Spinocerebellar Ataxia. Am. J. Hum. Genet., 101(1):87-103. https://doi.org/10.1016/j.ajhg.2017.06.007

Liu, X., Freitas, J., Zheng, D., Oliveira, M. S., Hoque, M., Martins, T., Henriques, T., Tian, B., and Moreira, A. (2017), Transcription elongation rate has a tissue-specific impact on alternative cleavage and 3 polyadenylation in Drosophila melanogaster. RNA, 23(12), 1807-1816. https://doi.org/10.1261/rna.062661.117

Macedo, J. C., Vaz, S., Logarinho, E. (2017), Mitotic dysfunction associated with aging hallmarks. Adv. Exp. Med. Biol., 1002:153-188. https://doi.org/10.1007/978-3-319-57127-0_7 (Book Chapter)

Cereija, T. B., Alarico, S., Empadinhas, N., Pereira, P. J. B. (2017), Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase. Acta Crystallogr. F Struct. Biol. Commun., 73(Pt 9):536-540. https://doi.org/10.1107/S2053230X17012419

Fonseca, K.L., Rodrigues, P. N. S., Olsson, I. A. S., Saraiva, M. (2017), Experimental study of tuberculosis: From animal models to complex cell systems and organoids. PloS Pathog. 13(8):e1006421. https://doi.org/10.1371/journal.ppat.1006421

 

2016

Moreira-Teixeira L, Sousa J, McNab FW, Torrado E, Cardoso F, Machado H, Castro F, Cardoso V, Gaifem J, Wu X, Appelberg R, Castro AG, O'Garra A, Saraiva M. Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling. J Immunol. (2016),15;197(12):4714-4726. PMID:27849167

Szollosi, A., Vieira-Pires, R. S., Teixeira-Duarte, C. M., Rocha, R., & Morais-Cabral, J. H. (2016). Dissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the KtrAB K+ Transporter. PLoS Biol, 14(1), e1002356. https://doi.org/10.1371/journal.pbio.1002356

Moreira, S., and Morais-de-Sá, E. (2016). Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons. BioArchitecture 6, 29–38. https://doi.org/10.1080/19490992.2016.1149290

De Munter S, Verheijden S, Vanderstuyft E, Malheiro AR, Brites P, Gall D, Schiffmann SN, Baes M. (2016) “Early-onset Purkinje cell dysfunction underlies cerebellar ataxia in peroxisomal multifunctional protein-2 deficiency”, Neurobiol Dis, Oct;94:157-68. https://doi.org/10.1016/j.nbd.2016.06.012

Leite, S. C., Sampaio, P., Sousa, V. F., Nogueira-Rodrigues, J., Pinto-Costa, R., Peters, L.L., Brites, P., Sousa, M. M. (2016), The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter. Cell Rep., 15(3):490-498. https://doi.org/10.1016/j.celrep.2016.03.047

Teixeira, C. A., Almeida, M. R., Saraiva, M.J. (2016), Impairment of autophagy by TTR V30M aggregates: in vivo reversal by TUDCA and curcumin. Clin. Sci. (Lond), 130(18):1665-75. https://doi.org/10.1042/CS20160075

Loureiro, J. R., Oliveira, C. L., Silveira, I. (2016), Unstable repeat expansions in neurodegenerative diseases: nucleocytoplasmic transport emerges on the scene. Neurobiol. Aging, 39:174-183. https://doi.org/10.1016/j.neurobiolaging.2015.12.007 (Review)

 

2015

Malheiro AR, Ferreira da Silva T, and Brites P. (2015) “Plasmalogens and fatty alcohols in Rhizomelic Chondrodysplasia Punctata and Sjogren-Larsson syndrome”, J Inherit Metab Dis, Jan;38(1):111-21. https://doi.org/10.1007/s10545-014-9795-3


Home | Site Map | Contacts | Credits |